Description
| 抗体名: | SYNE3 Antibody (PACO22457) |
| 抗体コード: | PACO22457 |
| サイズ: | 100ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB |
| 推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
| 反応性: | Human, Mouse |
| 免疫原: | Synthesized peptide derived from internal of human C14orf49. |
| 憲法: | Liquid |
| ストレージバッファ: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from Jurkat cells, using C14orf49 antibody. |
| バックグラウンド: | Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Involved in the maintenance of nuclear organization and structural integrity. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system. Plays a role in the regulation of aortic epithelial cell morphology, and is required for flow-induced centrosome polarization and directional migration in aortic endothelial cells. |
| シノニム: | nesprin-3; SYNE3; |
| UniProt Protein Function: | SYNE3: Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Involved in the maintenance of nuclear organization and structural integrity. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system. Plays a role in the regulation of aortic epithelial cell morphology, and is required for flow- induced centrosome polarization and directional migration in aortic endothelial cells. Belongs to the nesprin family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 14q32.13 Cellular Component: membrane; nuclear envelope Molecular Function:actin filament binding; protein binding Biological Process: cytoskeleton organization and biogenesis; regulation of cell shape |
| UniProt Code: | Q6ZMZ3 |
| NCBI GenInfo Identifier: | 134035037 |
| NCBI Gene ID: | 161176 |
| NCBI Accession: | Q6ZMZ3.2 |
| UniProt Secondary Accession: | Q6ZMZ3,Q86SX5, Q8N7G8, A6H8H3, |
| UniProt Related Accession: | Q6ZMZ3 |
| Molecular Weight: | 68,582 Da |
| NCBI Full Name: | Nesprin-3 |
| NCBI Synonym Full Names: | spectrin repeat containing nuclear envelope family member 3 |
| NCBI Official Symbol: | SYNE3 |
| NCBI Official Synonym Symbols: | NET53; Nesp3; C14orf49 |
| NCBI Protein Information: | nesprin-3 |
| UniProt Protein Name: | Nesprin-3 |
| UniProt Synonym Protein Names: | Nuclear envelope spectrin repeat protein 3 |
| Protein Family: | Nesprin |
| UniProt Gene Name: | SYNE3 |
| UniProt Entry Name: | SYNE3_HUMAN |
