Description
| 抗体名: | STK17B Antibody (PACO15775) |
| 抗体コード: | PACO15775 |
| サイズ: | 50ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, IHC |
| 推奨される希釈: | ELISA:1:1000-1:5000, IHC:1:50-1:200 |
| 反応性: | Human, Mouse, Rat |
| 免疫原: | Fusion protein of human STK17B |
| 憲法: | Liquid |
| ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| 精製方法: | Antigen affinity purification |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO15775(STK17B Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO15775(STK17B Antibody) at dilution 1/40, on the right is treated with fusion protein. (Original magnification: x200). |
| バックグラウンド: | The full-length STK17B cDNA clone encodes a deduced 372-amino acid, protein with a molecular mass of 42.34 kD. The putative kinase domain is located at the N terminus and contains all 11 subdomains conserved among ser/thr kinases. STK17A and STK17B share 59.7% amino acid, identity. Northern blot analysis revealed that STK17B was expressed in various tissues, such as heart, placenta, liver, and pancreas, as different-sized transcripts, presumably due to differences in the 3-prime untranslated region. Transient transfection of COS-7 cells showed that STK17B localized in nuclei. Phosphorylates myosin light chains. Acts as a positive regulator of apoptosis. |
| シノニム: | serine/threonine kinase 17b |
| UniProt Protein Function: | DRAK2: a calmodulin-dependent kinase of the DAPK family. Interacts with and is regulated by calcineurin homologous protein (CHP), an EF-hand Ca(2+)-binding protein. In vitro, CHP inhibits the apoptosis-inducing protein kinase DRAK2 in the presence of elevated Ca(2+) levels. Highly expressed in placenta, lung, pancreas. Lower levels in heart, brain, liver, skeletal muscle and kidney.Protein type: EC 2.7.11.1; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; CAMK group; DAPK familyChromosomal Location of Human Ortholog: 2q32.3Cellular Component: nucleusMolecular Function: ATP binding; protein kinase activity; protein serine/threonine kinase activityBiological Process: protein amino acid autophosphorylation; protein amino acid phosphorylation |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | O94768 |
| NCBI GenInfo Identifier: | 14423909 |
| NCBI Gene ID: | 9262 |
| NCBI Accession: | O94768.1 |
| UniProt Secondary Accession: | O94768 |
| UniProt Related Accession: | O94768 |
| Molecular Weight: | 42,344 Da |
| NCBI Full Name: | Serine/threonine-protein kinase 17B |
| NCBI Synonym Full Names: | serine/threonine kinase 17b |
| NCBI Official Symbol: | STK17B |
| NCBI Official Synonym Symbols: | DRAK2 |
| NCBI Protein Information: | serine/threonine-protein kinase 17B |
| UniProt Protein Name: | Serine/threonine-protein kinase 17B |
| UniProt Synonym Protein Names: | DAP kinase-related apoptosis-inducing protein kinase 2 |
| Protein Family: | Serine/threonine-protein kinase |
| UniProt Gene Name: | STK17B |
| UniProt Entry Name: | ST17B_HUMAN |
| Antibodies |
| STK17B Antibody (PACO06435) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
