The Spock1 Monoclonal Antibody (PAC046618) is a cutting-edge tool for researchers studying Spock1, a protein involved in extracellular matrix remodeling and cell adhesion. This antibody, produced in mice, shows high specificity for Spock1 in human samples and is validated for use in immunofluorescence and immunohistochemistry applications. By detecting and quantifying Spock1 expression, researchers can further explore its role in processes such as tissue development, wound healing, and cancer metastasis.
Spock1, a member of the Spock family of proteoglycans, is known for its ability to modify the extracellular matrix, which is essential for cell migration, differentiation, and signaling. Dysregulation of Spock1 has been linked to various pathological conditions, making it a promising target for therapeutic interventions. Investigating the functions and mechanisms of Spock1 could lead to novel treatments for diseases affecting tissue structure and function.
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO46618 at dilution of 1:100.
Western Blot. Positive WB detected in: Mouse brain tissue. All lanes: SPOCK1 antibody at 1:3000. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 50 kDa. Observed band size: 50 kDa.
Immunofluorescent analysis of HepG2 cells using PACO46618 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
May play a role in cell-cell and cell-matrix interactions. May contribute to various neuronal mechanisms in the central nervous system.
SPOCK1: May play a role in cell-cell and cell-matrix interactions. May contribute to various neuronal mechanisms in the central nervous system.Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide; Cell adhesionChromosomal Location of Human Ortholog: 5q31.2Cellular Component: proteinaceous extracellular matrix; extracellular space; postsynaptic density; cytoplasm; neuromuscular junction; sarcoplasmMolecular Function: serine-type endopeptidase inhibitor activity; metalloendopeptidase inhibitor activity; calcium ion binding; cysteine protease inhibitor activityBiological Process: nervous system development; central nervous system neuron differentiation; neurogenesis; neuron migration; regulation of cell growth; signal transduction; cell adhesion
UniProt Protein Details:
NCBI Summary:
This gene encodes the protein core of a seminal plasma proteoglycan containing chondroitin- and heparan-sulfate chains. The protein's function is unknown, although similarity to thyropin-type cysteine protease-inhibitors suggests its function may be related to protease inhibition. [provided by RefSeq, Jul 2008]
