Description
| 抗体名: | SPIN1 Antibody (PACO21996) |
| 抗体コード: | PACO21996 |
| サイズ: | 100ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB |
| 推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
| 反応性: | Human, Mouse, Rat |
| 免疫原: | Synthesized peptide derived from internal of human SPIN1. |
| 憲法: | Liquid |
| ストレージバッファ: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from HeLa cells, using SPIN1 antibody. |
| バックグラウンド: | Chromatin reader that specifically recognizes and binds histone H3 both trimethylated at 'Lys-4' and asymmetrically dimethylated at 'Arg-8' (H3K4me3 and H3R8me2a) and acts as an activator of Wnt signaling pathway dowstream of PRMT2. In case of cancer, promotes cell cancer proliferation via activation of the Wnt signaling pathway (). Overexpression induces metaphase arrest and chromosomal instability. Localizes to active rDNA loci and promotes the expression of rRNA genes (). May play a role in cell-cycle regulation during the transition from gamete to embryo. Involved in oocyte meiotic resumption, a process that takes place before ovulation to resume meiosis of oocytes blocked in prophase I: may act by regulating maternal transcripts to control meiotic resumption. Gao Y., Biochem. Biophys. Res. Commun. 335:343-350(2005). |
| シノニム: | OCR; Ovarian cancer-related protein; Spindlin-1; |
| UniProt Protein Function: | SPIN1: May play a role in cell-cycle regulation during the transition from gamete to embryo. Belongs to the SPIN/STSY family. |
| UniProt Protein Details: | Protein type:Nucleolus; DNA-binding Chromosomal Location of Human Ortholog: 9q22.1 Cellular Component: nucleolus; spindle; nucleus Molecular Function:protein binding; methylated histone residue binding Biological Process: Wnt receptor signaling pathway; meiotic cell cycle; multicellular organismal development; gamete generation; chromatin modification; positive regulation of Wnt receptor signaling pathway; rRNA transcription |
| UniProt Code: | Q9Y657 |
| NCBI GenInfo Identifier: | 93141317 |
| NCBI Gene ID: | 10927 |
| NCBI Accession: | Q9Y657.3 |
| UniProt Secondary Accession: | Q9Y657,Q7KZJ8, Q9GZT2, Q9H0N7, A8K0X6, B3KRQ4, |
| UniProt Related Accession: | Q9Y657 |
| Molecular Weight: | Calculated MW: 29kDaObserved MW: 32kDa |
| NCBI Full Name: | Spindlin-1 |
| NCBI Synonym Full Names: | spindlin 1 |
| NCBI Official Symbol: | SPIN1 |
| NCBI Official Synonym Symbols: | SPIN |
| NCBI Protein Information: | spindlin-1; ovarian cancer-related protein; spindlin1 |
| UniProt Protein Name: | Spindlin-1 |
| UniProt Synonym Protein Names: | Ovarian cancer-related protein; Spindlin1 |
| Protein Family: | Spindlin |
| UniProt Gene Name: | SPIN1 |
| UniProt Entry Name: | SPIN1_HUMAN |
