| UniProt Protein Function: | SOX5: Binds specifically to the DNA sequence 5'-AACAAT-3'. Activates transcription of COL2A1 and AGC1 in vitro. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transcription factor; DNA-binding Chromosomal Location of Human Ortholog: 12p12.1 Molecular Function:protein binding; protein heterodimerization activity; transcription factor activity Biological Process: transcription from RNA polymerase II promoter; central nervous system neuron differentiation; cell fate commitment; positive regulation of chondrocyte differentiation; in utero embryonic development; cartilage development; regulation of timing of neuron differentiation; oligodendrocyte differentiation; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent |
| NCBI Summary: | This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. The encoded protein may play a role in chondrogenesis. A pseudogene of this gene is located on chromosome 8. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P35711 |
| NCBI GenInfo Identifier: | 30179883 |
| NCBI Gene ID: | 6660 |
| NCBI Accession: | P35711.3 |
| UniProt Related Accession: | P35711 |
| Molecular Weight: | ~ 70kDa |
| NCBI Full Name: | Transcription factor SOX-5 |
| NCBI Synonym Full Names: | SRY-box transcription factor 5 |
| NCBI Official Symbol: | SOX5 |
| NCBI Official Synonym Symbols: | L-SOX5; LAMSHF; L-SOX5B; L-SOX5F |
| NCBI Protein Information: | transcription factor SOX-5 |
| UniProt Protein Name: | Transcription factor SOX-5 |
| Protein Family: | Transcription factor |
| UniProt Gene Name: | SOX5 |
| UniProt Entry Name: | SOX5_HUMAN |
