| UniProt Protein Function: | SOX14: Acts as a negative regulator of transcription. |
| UniProt Protein Details: | Protein type:DNA-binding; Transcription factor Chromosomal Location of Human Ortholog: 3q22-q23 Molecular Function:protein heterodimerization activity; sequence-specific DNA binding; chromatin binding Biological Process: transcription from RNA polymerase II promoter; nervous system development; visual perception; entrainment of circadian clock; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent |
| NCBI Summary: | This intronless gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. Mutations in this gene are suggested to be responsible for the limb defects associated with blepharophimosis, ptosis, epicanthus inversus syndrome (BPES) and Mobius syndrome. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O95416 |
| NCBI GenInfo Identifier: | 6831689 |
| NCBI Gene ID: | 8403 |
| NCBI Accession: | O95416.1 |
| UniProt Secondary Accession: | O95416,Q3KPH7, B2RAC0, |
| UniProt Related Accession: | O95416 |
| Molecular Weight: | 240 |
| NCBI Full Name: | Transcription factor SOX-14 |
| NCBI Synonym Full Names: | SRY (sex determining region Y)-box 14 |
| NCBI Official Symbol: | SOX14 |
| NCBI Official Synonym Symbols: | SOX28 |
| NCBI Protein Information: | transcription factor SOX-14; SRY-box 14; HMG box transcription factor SOX-14 |
| UniProt Protein Name: | Transcription factor SOX-14 |
| UniProt Synonym Protein Names: | Protein SOX-28 |
| Protein Family: | Transcription factor |
| UniProt Gene Name: | SOX14 |
| UniProt Entry Name: | SOX14_HUMAN |
