The SNX27 Polyclonal Antibody (PAC017132) is a valuable tool for researchers studying SNX27, a key protein involved in endosomal trafficking and sorting. Raised in rabbits, this antibody has been validated for use in various applications, including Western blot and immunofluorescence, and exhibits high reactivity with human samples.SNX27 plays a crucial role in the regulation of protein trafficking within cells, particularly in the recycling of cell surface receptors and the formation of specialized endosomal compartments.
Dysregulation of SNX27 has been linked to various diseases, including neurodegenerative disorders and cancer, making it a promising target for therapeutic intervention.This antibody enables specific detection and analysis of SNX27 in different cell types, providing valuable insights into its function and potential implications in disease pathology. Its use in research can lead to a better understanding of intracellular trafficking mechanisms and the development of targeted therapies for relevant conditions.
Antibody Name:
SNX27 Antibody (PACO17132)
Antibody SKU:
PACO17132
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:1000-1:2000, IHC:1:10-1:50
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Fusion protein of human SNX27
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO17132(SNX27 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO17132(SNX27 Antibody) at dilution 1/20, on the right is treated with fusion protein. (Original magnification: x200).
Background:
This gene encodes a member of the sorting nexin family, a diverse group of cytoplasmic and membrane-associated proteins involved in endocytosis of plasma membrane receptors and protein trafficking through these compartments. All members of this protein family contain a phosphoinositide binding domain (PX domain). A highly similar protein in mouse is responsible for the specific recruitment of an isoform of serotonin 5-hydroxytryptamine 4 receptor into early endosomes, suggesting the analogous role for the human protein.
Synonyms:
sorting nexin family member 27
UniProt Protein Function:
SNX27: Involved in endocytic trafficking. In T lymphocytes, participates in endocytic recycling pathway. Recruits PSCDBP and HT4R to early endosomes. Belongs to the sorting nexin family. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:
Protein type:Vesicle
Chromosomal Location of Human Ortholog: 1q21.3
Cellular Component: cytoplasm; early endosome; immunological synapse; nucleoplasm; retromer complex
Molecular Function:phosphatidylinositol 3-phosphate binding; protein binding
Biological Process: endosome transport; establishment of natural killer cell polarity; intracellular protein transport
NCBI Summary:
This gene encodes a member of the sorting nexin family, a diverse group of cytoplasmic and membrane-associated proteins involved in endocytosis of plasma membrane receptors and protein trafficking through these compartments. All members of this protein family contain a phosphoinositide binding domain (PX domain). A highly similar protein in mouse is responsible for the specific recruitment of an isoform of serotonin 5-hydroxytryptamine 4 receptor into early endosomes, suggesting the analogous role for the human protein. [provided by RefSeq, Jul 2008]
