| UniProt Protein Function: | SMYD3: Histone methyltransferase. Specifically methylates 'Lys- 4' of histone H3, inducing di- and tri-methylation, but not monomethylation. Plays an important role in transcriptional activation as a member of an RNA polymerase complex. Binds DNA containing 5'-CCCTCC-3' or 5'-GAGGGG-3' sequences. Belongs to the histone-lysine methyltransferase family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 2.1.1.43; Methyltransferase, protein lysine; Methyltransferase Chromosomal Location of Human Ortholog: 1q44 Cellular Component: nucleoplasm; cytoplasm Molecular Function:metal ion binding; histone-lysine N-methyltransferase activity Biological Process: nucleosome assembly; establishment and/or maintenance of chromatin architecture; establishment of protein localization; myotube cell development; negative regulation of protein kinase activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of peptidyl-serine phosphorylation |
| NCBI Summary: | This gene encodes a histone methyltransferase which functions in RNA polymerase II complexes by an interaction with a specific RNA helicase. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011] |
| UniProt Code: | Q9H7B4 |
| NCBI GenInfo Identifier: | 212276523 |
| NCBI Gene ID: | 64754 |
| NCBI Accession: | Q9H7B4.4 |
| UniProt Secondary Accession: | Q9H7B4,Q86TL8, Q8N5Z6, Q96AI5, A8K0P0, B1AN38, |
| UniProt Related Accession: | Q9H7B4 |
| Molecular Weight: | 428 |
| NCBI Full Name: | Histone-lysine N-methyltransferase SMYD3 |
| NCBI Synonym Full Names: | SET and MYND domain containing 3 |
| NCBI Official Symbol: | SMYD3 |
| NCBI Official Synonym Symbols: | KMT3E; ZMYND1; ZNFN3A1; bA74P14.1 |
| NCBI Protein Information: | histone-lysine N-methyltransferase SMYD3; bA74P14.1 (novel protein); zinc finger, MYND domain containing 1; SET and MYND domain-containing protein 3; zinc finger MYND domain-containing protein 1; zinc finger protein, subfamily 3A (MYND domain containing) |
| UniProt Protein Name: | Histone-lysine N-methyltransferase SMYD3 |
| UniProt Synonym Protein Names: | SET and MYND domain-containing protein 3; Zinc finger MYND domain-containing protein 1 |
| Protein Family: | Histone-lysine N-methyltransferase |
| UniProt Gene Name: | SMYD3 |
| UniProt Entry Name: | SMYD3_HUMAN |
