The SMC1 Rabbit Monoclonal Antibody (CAB4693) is a high-quality antibody designed for research involving SMC1, a key component of the cohesin complex that plays a crucial role in maintaining genome stability and regulating gene expression. This monoclonal antibody, developed in rabbits, is highly specific and sensitive for detecting SMC1 in human samples, making it an essential tool for studies in molecular biology and cancer research.SMC1 is involved in the process of DNA repair, replication, and chromosome segregation, making it a significant target for understanding mechanisms of genomic integrity and cell cycle progression.
Dysregulation of SMC1 has been linked to various diseases, including cancer, making it a promising target for therapeutic interventions.With its high reactivity and specificity, the SMC1 Rabbit Monoclonal Antibody (CAB4693) is a valuable tool for researchers looking to explore the functions and signaling pathways of SMC1 in different cellular processes, providing insights that can lead to novel therapeutic strategies in the field of oncology and genetic disorders.
Product Name:
SMC1 Rabbit Monoclonal Antibody
SKU:
CAB4693
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1134-1233 of human SMC1 (Q14683).
Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1B or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. Mutations in this gene result in Cornelia de Lange syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
8243
Clone Number:
ARC1095
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using SMC1 Rabbit mAb (CAB4693) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3s.
