The SLC35B4 Polyclonal Antibody (PAC039786) is a valuable tool for researchers studying the SLC35B4 protein, a member of the SLC35 family involved in nucleotide sugar transport. This antibody, generated in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the SLC35B4 protein, this antibody allows for the detection and analysis of SLC35B4 expression in various cell types, making it an essential component for studies in glycobiology and metabolic research.SLC35B4 is essential for the transport of nucleotide sugars into the Golgi apparatus, where they serve as substrates for glycosylation reactions.
Dysregulation of SLC35B4 expression has been implicated in various diseases, including metabolic disorders and cancer. Therefore, understanding the function and regulation of SLC35B4 is crucial for developing targeted therapies aimed at modulating glycosylation pathways in disease contexts.By utilizing the SLC35B4 Polyclonal Antibody (PAC039786), researchers can delve deeper into the role of SLC35B4 in cellular processes, paving the way for novel insights and potential therapeutic interventions in the future.
Antibody Name:
SLC35B4 Antibody (PACO39786)
Antibody SKU:
PACO39786
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IF
Recommended Dilutions:
ELISA:1:2000-1:10000, IF:1:50-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human UDP-xylose and UDP-N-acetylglucosamine transporter protein (174-200AA)
Immunofluorescent analysis of A2780 cells using PACO39786 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Background:
Sugar transporter that specifically mediates the transport of UDP-xylose (UDP-Xyl) and UDP-N-acetylglucosamine (UDP-GlcNAc) from cytosol into Golgi.
Synonyms:
UDP-xylose and UDP-N-acetylglucosamine transporter (Solute carrier family 35 member B4) (YEA4 homolog), SLC35B4, YEA4
UniProt Protein Function:
Sugar transporter that specifically mediates the transport of UDP-xylose (UDP-Xyl) and UDP-N-acetylglucosamine (UDP-GlcNAc) from cytosol into Golgi.
UniProt Protein Details:
NCBI Summary:
Glycosyltransferases, such as SLC35B4, transport nucleotide sugars from the cytoplasm where they are synthesized, to the Golgi apparatus where they are utilized in the synthesis of glycoproteins, glycolipids, and proteoglycans (Ashikov et al., 2005 [PubMed 15911612]).[supplied by OMIM, Mar 2008]
