Description
| 抗体名: | SLC25A4 Antibody (PACO29932) |
| 抗体コード: | PACO29932 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, IHC, IF |
| 推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:20-1:200, IF:1:50-1:500 |
| 反応性: | Human |
| 免疫原: | Recombinant Human ADP/ATP translocase 1 protein (40-74AA) |
| 憲法: | Liquid |
| ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| 精製方法: | >95%, Protein G purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human small intestine tissue using PACO29932 at dilution of 1:100. |
 | Immunofluorescence staining of PC-3 cells with PACO29932 at 1:266, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | Immunohistochemistry of paraffin-embedded human breast cancer using PACO29932 at dilution of 1:100. |
| バックグラウンド: | Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. |
| シノニム: | ADP/ATP translocase 1 (ADP,ATP carrier protein 1) (ADP,ATP carrier protein, heart/skeletal muscle isoform T1) (Adenine nucleotide translocator 1) (ANT 1) (Solute carrier family 25 member 4), SLC25A4, ANT1 |
| UniProt Protein Function: | SLC25A4: Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. Defects in SLC25A4 are a cause of progressive external ophthalmoplegia with mitochondrial DNA deletions autosomal dominant type 2 (PEOA2). Progressive external ophthalmoplegia is characterized by progressive weakness of ocular muscles and levator muscle of the upper eyelid. In a minority of cases, it is associated with skeletal myopathy, which predominantly involves axial or proximal muscles and which causes abnormal fatigability and even permanent muscle weakness. Ragged- red fibers and atrophy are found on muscle biopsy. A large proportion of chronic ophthalmoplegias are associated with other symptoms, leading to a multisystemic pattern of this disease. Additional symptoms are variable, and may include cataracts, hearing loss, sensory axonal neuropathy, ataxia, depression, hypogonadism, and parkinsonism. Belongs to the mitochondrial carrier family. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Membrane protein, integral; Transporter; Transporter, SLC family; Mitochondrial Chromosomal Location of Human Ortholog: 4q35 Cellular Component: mitochondrion; integral to plasma membrane; mitochondrial inner membrane; nucleus Molecular Function:protein binding; adenine transmembrane transporter activity Biological Process: adenine transport; mitochondrial genome maintenance; apoptotic mitochondrial changes; generation of precursor metabolites and energy; viral reproduction; transport; energy reserve metabolic process; regulation of insulin secretion; transmembrane transport Disease: Mitochondrial Dna Depletion Syndrome 12 (cardiomyopathic Type); Progressive External Ophthalmoplegia With Mitochondrial Dna Deletions, Autosomal Dominant, 2 |
| NCBI Summary: | This gene is a member of the mitochondrial carrier subfamily of solute carrier protein genes. The product of this gene functions as a gated pore that translocates ADP from the cytoplasm into the mitochondrial matrix and ATP from the mitochondrial matrix into the cytoplasm. The protein forms a homodimer embedded in the inner mitochondria membrane. Mutations in this gene have been shown to result in autosomal dominant progressive external opthalmoplegia and familial hypertrophic cardiomyopathy. [provided by RefSeq, Jun 2013] |
| UniProt Code: | P12235 |
| NCBI GenInfo Identifier: | 113455 |
| NCBI Gene ID: | 291 |
| NCBI Accession: | P12235.4 |
| UniProt Secondary Accession: | P12235,D3DP59, |
| UniProt Related Accession: | P12235 |
| Molecular Weight: | 298 |
| NCBI Full Name: | ADP/ATP translocase 1 |
| NCBI Synonym Full Names: | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 |
| NCBI Official Symbol: | SLC25A4 |
| NCBI Official Synonym Symbols: | 1; T1; ANT; AAC1; ANT1; PEO2; PEO3; ANT 1; MTDPS12 |
| NCBI Protein Information: | ADP/ATP translocase 1; ADP,ATP carrier protein 1; solute carrier family 25 member 4; heart/skeletal muscle ATP/ADP translocator; ADP,ATP carrier protein, heart/skeletal muscle; adenine nucleotide translocator 1 (skeletal muscle) |
| UniProt Protein Name: | ADP/ATP translocase 1 |
| UniProt Synonym Protein Names: | ADP,ATP carrier protein 1; ADP,ATP carrier protein, heart/skeletal muscle isoform T1; Adenine nucleotide translocator 1; ANT 1; Solute carrier family 25 member 4 |
| Protein Family: | ADP/ATP translocase |
| UniProt Gene Name: | SLC25A4 |
| UniProt Entry Name: | ADT1_HUMAN |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
