| UniProt Protein Function: | SLC25A37: Mitochondrial iron transporter that specifically mediates iron uptake in developing erythroid cells, thereby playing an essential role in heme biosynthesis. The iron delivered into the mitochondria, presumably as Fe(2+), is then probably delivered to ferrochelatase to catalyze Fe(2+) incorporation into protoprophyrin IX to make heme. Belongs to the mitochondrial carrier family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Mitochondrial; Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 8p21.2Molecular Function: structural constituent of ribosomeBiological Process: translation |
| UniProt Protein Details: | |
| NCBI Summary: | SLC25A37 is a solute carrier localized in the mitochondrial inner membrane. It functions as an essential iron importer for the synthesis of mitochondrial heme and iron-sulfur clusters (summary by Chen et al., 2009 [PubMed 19805291]).[supplied by OMIM, Jan 2011] |
| UniProt Code: | Q9NYZ2 |
| NCBI GenInfo Identifier: | 189047115 |
| NCBI Gene ID: | 51312 |
| NCBI Accession: | Q9NYZ2.2 |
| UniProt Secondary Accession: | Q9NYZ2,Q53FT7, Q69YJ8, Q969S1, Q9P0J2, A2RU93 |
| UniProt Related Accession: | Q9NYZ2 |
| Molecular Weight: | 21,125 Da |
| NCBI Full Name: | Mitoferrin-1 |
| NCBI Synonym Full Names: | solute carrier family 25 member 37 |
| NCBI Official Symbol: | SLC25A37 |
| NCBI Official Synonym Symbols: | MSC; MFRN; MSCP; HT015; MFRN1; PRO1278; PRO1584; PRO2217 |
| NCBI Protein Information: | mitoferrin-1 |
| UniProt Protein Name: | Mitoferrin-1 |
| UniProt Synonym Protein Names: | Mitochondrial iron transporter 1; Mitochondrial solute carrier protein; Solute carrier family 25 member 37 |
| Protein Family: | Mitoferrin |
| UniProt Gene Name: | SLC25A37 |
| UniProt Entry Name: | MFRN1_HUMAN |
