Description
| 抗体名: | SLC1A5 Antibody (PACO44928) |
| 抗体コード: | PACO44928 |
| サイズ: | 50ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, IHC |
| 推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| 反応性: | Human |
| 免疫原: | Recombinant Human Neutral amino acid, transporter B(0) protein (1-100AA) |
| 憲法: | Liquid |
| ストレージバッファ: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 精製方法: | Antigen Affinity Purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using PACO44928 at dilution of 1:100. |
| バックグラウンド: | Sodium-dependent amino acid, transporter that has a broad substrate specificity, with a preference for zwitterionic amino acid,. It accepts as substrates all neutral amino acid, , including glutamine, asparagine, and branched-chain and aromatic amino acid, , and excludes methylated, anionic, and cationic amino acid,. May also be activated by insulin. Through binding of the fusogenic protein syncytin-1/ERVW-1 may mediate trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development. Acts as a cell surface receptor for feline endogenous virus RD114, baboon M7 endogenous virus and type D simian retroviruses. |
| シノニム: | Neutral amino acid, transporter B(0) (ATB(0)) (Baboon M7 virus receptor) (RD114/simian type D retrovirus receptor) (Sodium-dependent neutral amino acid, transporter type 2) (Solute carrier family 1 member 5), SLC1A5, ASCT2 M7V1 RDR RDRC |
| UniProt Protein Function: | SLC1A5: Has a broad substrate specificity, a preference for zwitterionic amino acids, and a sodium-dependence. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated amino acids, anionic amino acids, and cationic amino acids. Act as a cell surface receptor for feline endogenous virus RD114, baboon M7 endogenous virus and type D simian retroviruses. Placenta, lung, skeletal muscle, kidney, pancreas, and intestine. Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. SLC1A5 subfamily. 1 isoforms of the human protein are produced by alternative initiation. |
| UniProt Protein Details: | Protein type:Transporter; Transporter, SLC family; Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 19q13.3 Cellular Component: Golgi apparatus; integral to plasma membrane; membrane; plasma membrane Molecular Function:amino acid transmembrane transporter activity; L-glutamine transmembrane transporter activity; neutral amino acid transmembrane transporter activity; protein binding; receptor activity Biological Process: amino acid transport; glutamine transport; neutral amino acid transport |
| NCBI Summary: | The SLC1A5 gene encodes a sodium-dependent neutral amino acid transporter that can act as a receptor for RD114/type D retrovirus (Larriba et al., 2001 [PubMed 11781704]).[supplied by OMIM, Jan 2011] |
| UniProt Code: | Q15758 |
| NCBI GenInfo Identifier: | 21542389 |
| NCBI Gene ID: | 6510 |
| NCBI Accession: | Q15758.2 |
| UniProt Secondary Accession: | Q15758,O95720, Q96RL9, Q9BWQ3, Q9UNP2, A8K9H5, B4DR77 B4DWS4, B7ZB81, D0EYG6, E9PC01, |
| UniProt Related Accession: | Q15758 |
| Molecular Weight: | 33,710 Da |
| NCBI Full Name: | Neutral amino acid transporter B(0) |
| NCBI Synonym Full Names: | solute carrier family 1 member 5 |
| NCBI Official Symbol: | SLC1A5 |
| NCBI Official Synonym Symbols: | R16; AAAT; ATBO; M7V1; RDRC; ASCT2; M7VS1 |
| NCBI Protein Information: | neutral amino acid transporter B(0) |
| UniProt Protein Name: | Neutral amino acid transporter B(0) |
| UniProt Synonym Protein Names: | Baboon M7 virus receptor; RD114/simian type D retrovirus receptor; Sodium-dependent neutral amino acid transporter type 2; Solute carrier family 1 member 5 |
| Protein Family: | Neutral amino acid transporter |
| UniProt Gene Name: | SLC1A5 |
| UniProt Entry Name: | AAAT_HUMAN |
