Description
| 抗体名: | SLC1A1 Antibody (PACO06443) |
| 抗体コード: | PACO06443 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB |
| 推奨される希釈: | ELISA:1:10000, WB:1:500-1:2000 |
| 反応性: | Human, Mouse, Rat |
| 免疫原: | Synthesized peptide derived from the Internal region of human EAAT3. |
| 憲法: | Liquid |
| ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| 精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot analysis of Jurkat cells using EAAT3 Polyclonal Antibody. |
 | Western Blot analysis of 293 cells using EAAT3 Polyclonal Antibody. |
| シノニム: | SLC1A1; EAAC1; EAAT3; Excitatory amino acid, transporter 3; Excitatory amino-acid, carrier 1; Neuronal and epithelial glutamate transporter; Sodium-dependent glutamate/aspartate transporter 3; Solute carrier family 1 member 1 |
| UniProt Protein Function: | SLC1A1: Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5. Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. SLC1A1 subfamily. |
| UniProt Protein Details: | Protein type:Transporter; Transporter, SLC family; Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 9p24 Cellular Component: membrane; integral to plasma membrane; apical plasma membrane; plasma membrane Molecular Function:glutamate binding; cysteine transmembrane transporter activity; sodium:dicarboxylate symporter activity; glutamate:sodium symporter activity; L-glutamate transmembrane transporter activity Biological Process: synaptic transmission; L-glutamate import; cysteine transport; ion transport; transmembrane transport; protein homooligomerization Disease: Schizophrenia 18 |
| NCBI Summary: | This gene encodes a member of the high-affinity glutamate transporters that play an essential role in transporting glutamate across plasma membranes. In brain, these transporters are crucial in terminating the postsynaptic action of the neurotransmitter glutamate, and in maintaining extracellular glutamate concentrations below neurotoxic levels. This transporter also transports aspartate, and mutations in this gene are thought to cause dicarboxylicamino aciduria, also known as glutamate-aspartate transport defect. [provided by RefSeq, Mar 2010] |
| UniProt Code: | P43005 |
| NCBI GenInfo Identifier: | 1352332 |
| NCBI Gene ID: | 6505 |
| NCBI Accession: | P43005.2 |
| UniProt Secondary Accession: | P43005,O75587, Q5VZ24, Q8N199, Q9UEW2, |
| UniProt Related Accession: | P43005 |
| Molecular Weight: | 57,100 Da |
| NCBI Full Name: | Excitatory amino acid transporter 3 |
| NCBI Synonym Full Names: | solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1 |
| NCBI Official Symbol: | SLC1A1 |
| NCBI Official Synonym Symbols: | DCBXA; EAAC1; EAAT3; SCZD18 |
| NCBI Protein Information: | excitatory amino acid transporter 3; excitatory amino acid carrier 1; solute carrier family 1 member 1; neuronal and epithelial glutamate transporter; sodium-dependent glutamate/aspartate transporter 3 |
| UniProt Protein Name: | Excitatory amino acid transporter 3 |
| UniProt Synonym Protein Names: | Excitatory amino-acid carrier 1; Neuronal and epithelial glutamate transporter; Sodium-dependent glutamate/aspartate transporter 3; Solute carrier family 1 member 1 |
| Protein Family: | Excitatory amino acid transporter |
| UniProt Gene Name: | SLC1A1 |
| UniProt Entry Name: | EAA3_HUMAN |
