Description
| 抗体名: | SKAP2 Antibody (PACO44304) |
| 抗体コード: | PACO44304 |
| サイズ: | 50ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, IHC |
| 推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| 反応性: | Human |
| 免疫原: | Recombinant Human Src kinase-associated phosphoprotein 2 protein (1-120AA) |
| 憲法: | Liquid |
| ストレージバッファ: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 精製方法: | Antigen Affinity Purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human colon cancer using PACO44304 at dilution of 1:100. |
| バックグラウンド: | May be involved in B-cell and macrophage adhesion processes. In B-cells, may act by coupling the B-cell receptor (BCR) to integrin activation. May play a role in src signaling pathway. |
| シノニム: | Src kinase-associated phosphoprotein 2 (Pyk2/RAFTK-associated protein) (Retinoic acid, induced protein 70) (SKAP55 homolog) (SKAP-55HOM) (SKAP-HOM) (Src family-associated phosphoprotein 2) (Src kinase-associated phosphoprotein 55-related protein) (Src-associated adapter protein with PH and SH3 domains), SKAP2, PRAP RA70 SAPS SCAP2 SKAP55R |
| UniProt Protein Function: | RA70: an ubiquitous adapter protein thought to play a role in the src signaling pathway. Contains a coiled-coil domain, a pleckstrin homology domain, and a SH3 domain. The SH3 domain binds to the proline-rich domain of Pyk2, inhibiting alpha-synuclein tyrosine phosphorylation. Can be phosphorylated by Src family kinases but not by Pyk2. Functions as a downstream target for Pyk2 and plays a role in alpha-synuclein phosphorylation. Negatively regulates alpha-synuclein phosphorylation following cell stress. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 7p15.2 Cellular Component: nucleoplasm; cytoplasm; plasma membrane; cytosol Molecular Function:protein binding; SH3/SH2 adaptor activity Biological Process: negative regulation of cell proliferation; B cell activation; positive regulation of signal transduction; protein complex assembly; signal transduction |
| NCBI Summary: | The protein encoded by this gene shares homology with Src kinase-associated phosphoprotein 1, and is a substrate of Src family kinases. It is an adaptor protein that is thought to play an essential role in the Src signaling pathway, and in regulating proper activation of the immune system. This protein contains an amino terminal coiled-coil domain for self-dimerization, a plecskstrin homology (PH) domain required for interactions with lipids at the membrane, and a Src homology (SH3) domain at the carboxy terminus. Some reports indicate that this protein inhibits actin polymerization through interactions with actin assembly factors, and might negatively regulate the invasiveness of tumors by modulating actin assembly. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2015] |
| UniProt Code: | O75563 |
| NCBI GenInfo Identifier: | 74735515 |
| NCBI Gene ID: | 8935 |
| NCBI Accession: | O75563.1 |
| UniProt Secondary Accession: | O75563,Q53GP6, Q75MK6, Q75MZ4, Q9UBZ3, Q9UED8, A4D173 |
| UniProt Related Accession: | O75563 |
| Molecular Weight: | 359 |
| NCBI Full Name: | Src kinase-associated phosphoprotein 2 |
| NCBI Synonym Full Names: | src kinase associated phosphoprotein 2 |
| NCBI Official Symbol: | SKAP2 |
| NCBI Official Synonym Symbols: | PRAP; RA70; SAPS; SCAP2; SKAP55R; SKAP-HOM |
| NCBI Protein Information: | src kinase-associated phosphoprotein 2; SKAP-55HOM; SKAP55 homolog; Pyk2/RAFTK-associated protein; retinoic acid-induced protein 70; src family-associated phosphoprotein 2; Fyn-associated phosphoprotein SKAP55 homologue; src-associated adapter protein with PH and SH3 domains; src kinase-associated phosphoprotein of 55-related protein |
| UniProt Protein Name: | Src kinase-associated phosphoprotein 2 |
| UniProt Synonym Protein Names: | Pyk2/RAFTK-associated protein; Retinoic acid-induced protein 70; SKAP55 homolog; SKAP-55HOM; SKAP-HOM; Src family-associated phosphoprotein 2; Src kinase-associated phosphoprotein 55-related protein; Src-associated adapter protein with PH and SH3 domains |
| Protein Family: | Src kinase-associated phosphoprotein |
| UniProt Gene Name: | SKAP2 |
| UniProt Entry Name: | SKAP2_HUMAN |
