Anti-SIX5 抗体 (PACO22380)

抗体名:	SIX5 Antibody (PACO22380)
抗体コード:	PACO22380
サイズ:	100ul
宿主種:	Rabbit
申し込み:	ELISA, WB
推奨される希釈:	ELISA:1:2000-1:10000, WB:1:500-1:3000
反応性:	Human, Mouse
免疫原:	Synthesized peptide derived from internal of human SIX5.

憲法:	Liquid
ストレージバッファ:	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
精製方法:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
抗体のクローン性:	Polyclonal
アイソタイプ:	IgG
Conjugate:	Non-conjugated

Western blot analysis of extracts from K562 cells, using SIX5 antibody.

バックグラウンド:

Transcription factor that is thought to be involved in regulation of organogenesis. May be involved in determination and maintenance of retina formation. Binds a 5'-GGTGTCAG-3' motif present in the ARE regulatory element of ATP1A1. Binds a 5'-TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the myogenin promoter, and in the IGFBP5 promoter By similarity. Thought to be regulated by association with Dach and Eya proteins, and seems to be coactivated by EYA1, EYA2 and EYA3 By similarity.

シノニム:

DM locus-associated homeodomain protein; DMAHP; homeobox protein SIX5;

UniProt Protein Function:	SIX5: Transcription factor that is thought to be involved in regulation of organogenesis. May be involved in determination and maintenance of retina formation. Binds a 5'-GGTGTCAG-3' motif present in the ARE regulatory element of ATP1A1. Binds a 5'- TCA[AG][AG]TTNC-3' motif present in the MEF3 element in the myogenin promoter, and in the IGFBP5 promoter. Thought to be regulated by association with Dach and Eya proteins, and seems to be coactivated by EYA1, EYA2 and EYA3. Defects in SIX5 are the cause of branchiootorenal syndrome type 2 (BOR2). BOR is an autosomal dominant disorder manifested by various combinations of preauricular pits, branchial fistulae or cysts, lacrimal duct stenosis, hearing loss, structural defects of the outer, middle, or inner ear, and renal dysplasia. Associated defects include asthenic habitus, long narrow facies, constricted palate, deep overbite, and myopia. Hearing loss may be due to mondini type cochlear defect and stapes fixation. Penetrance of BOR syndrome is high, although expressivity can be extremely variable. Belongs to the SIX/Sine oculis homeobox family.
UniProt Protein Details:	Protein type:Transcription factor; DNA-binding Chromosomal Location of Human Ortholog: 19q13.32 Cellular Component: cytoplasm; Golgi apparatus; intracellular membrane-bound organelle; nucleoplasm Molecular Function:protein binding Disease: Branchiootorenal Syndrome 2
NCBI Summary:	The protein encoded by this gene is a homeodomain-containing transcription factor that appears to function in the regulation of organogenesis. This gene is located downstream of the dystrophia myotonica-protein kinase gene. Mutations in this gene are a cause of branchiootorenal syndrome type 2. [provided by RefSeq, Jul 2009]
UniProt Code:	Q8N196
NCBI GenInfo Identifier:	150421671
NCBI Gene ID:	147912
NCBI Accession:	Q8N196.3
UniProt Related Accession:	Q8N196
Molecular Weight:	74,562 Da
NCBI Full Name:	Homeobox protein SIX5
NCBI Synonym Full Names:	SIX homeobox 5
NCBI Official Symbol:	SIX5
NCBI Official Synonym Symbols:	BOR2; DMAHP
NCBI Protein Information:	homeobox protein SIX5
UniProt Protein Name:	Homeobox protein SIX5
UniProt Synonym Protein Names:	DM locus-associated homeodomain protein; Sine oculis homeobox homolog 5
Protein Family:	Homeobox protein
UniProt Gene Name:	SIX5
UniProt Entry Name:	SIX5_HUMAN

Antibodies	ELISA Kits
Anti-SIX5 Antibody (CAB15960)	SIX5 Transcription Factor Activity Assay
SIX5 Antibody (PACO02508)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)