| UniProt Protein Function: | Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. |
| NCBI Summary: | This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin (Siglec) family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. The encoded protein is a member of the CD33-related subset of Siglecs and inhibits the activation of several cell types including monocytes, macrophages and neutrophils. Binding of group B Streptococcus (GBS) to the encoded protein plays a role in GBS immune evasion. [provided by RefSeq, Feb 2012] |
| UniProt Code: | O15389 |
| NCBI GenInfo Identifier: | 25009254 |
| NCBI Gene ID: | 8778 |
| NCBI Accession: | O15389.1 |
| UniProt Related Accession: | O15389 |
| Molecular Weight: | 60,715 Da |
| NCBI Full Name: | Sialic acid-binding Ig-like lectin 5 |
| NCBI Synonym Full Names: | sialic acid binding Ig like lectin 5 |
| NCBI Official Symbol: | SIGLEC5 |
| NCBI Official Synonym Symbols: | CD170; OBBP2; CD33L2; OB-BP2; SIGLEC-5 |
| NCBI Protein Information: | sialic acid-binding Ig-like lectin 5 |
| UniProt Protein Name: | Sialic acid-binding Ig-like lectin 5 |
| UniProt Synonym Protein Names: | CD33 antigen-like 2; Obesity-binding protein 2; OB-BP2; OB-binding protein 2; CD_antigen: CD170 |
| UniProt Gene Name: | SIGLEC5 |
