| UniProt Protein Function: | SIGLEC12: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Cell surface Chromosomal Location of Human Ortholog: 19q13.4 |
| NCBI Summary: | Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. This gene encodes a member of the SIGLEC3-like subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. The encoded protein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor. This gene is located in a cluster with other SIGLEC3-like genes on 19q13.4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013] |
| UniProt Code: | Q96PQ1 |
| NCBI GenInfo Identifier: | 25009264 |
| NCBI Gene ID: | 89858 |
| NCBI Accession: | Q96PQ1.1 |
| UniProt Secondary Accession: | Q96PQ1,Q8IYH7, |
| UniProt Related Accession: | Q96PQ1 |
| Molecular Weight: | 51,663 Da |
| NCBI Full Name: | Sialic acid-binding Ig-like lectin 12 |
| NCBI Synonym Full Names: | sialic acid binding Ig like lectin 12 (gene/pseudogene) |
| NCBI Official Symbol: | SIGLEC12 |
| NCBI Official Synonym Symbols: | S2V; SLG; SIGLECL1; Siglec-XII |
| NCBI Protein Information: | sialic acid-binding Ig-like lectin 12 |
| UniProt Protein Name: | Sialic acid-binding Ig-like lectin 12 |
| UniProt Synonym Protein Names: | Sialic acid-binding Ig-like lectin-like 1; Siglec-L1 |
| Protein Family: | Sialic acid-binding Ig-like lectin |
| UniProt Gene Name: | SIGLEC12 |
| UniProt Entry Name: | SIG12_HUMAN |
