| UniProt Protein Function: | SHMT1: Interconversion of serine and glycine. Belongs to the SHMT family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cofactor and Vitamin Metabolism - one carbon pool by folate; EC 2.1.2.1; Amino Acid Metabolism - glycine, serine and threonine; Energy Metabolism - methane; Other Amino Acids Metabolism - cyanoamino acid; Lyase; Methyltransferase; Mitochondrial Chromosomal Location of Human Ortholog: 17p11.2 Cellular Component: nucleoplasm; mitochondrion; cytoplasm; cytosol; nucleus Molecular Function:L-allo-threonine aldolase activity; amino acid binding; protein homodimerization activity; glycine hydroxymethyltransferase activity; pyridoxal phosphate binding Biological Process: purine base biosynthetic process; vitamin metabolic process; folic acid metabolic process; L-serine catabolic process; glycine biosynthetic process from serine; water-soluble vitamin metabolic process; carnitine biosynthetic process; protein tetramerization; protein homotetramerization |
| NCBI Summary: | This gene encodes the cytosolic form of serine hydroxymethyltransferase, a pyridoxal phosphate-containing enzyme that catalyzes the reversible conversion of serine and tetrahydrofolate to glycine and 5,10-methylene tetrahydrofolate. This reaction provides one-carbon units for synthesis of methionine, thymidylate, and purines in the cytoplasm. This gene is located within the Smith-Magenis syndrome region on chromosome 17. A pseudogene of this gene is located on the short arm of chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013] |
| UniProt Code: | P34896 |
| NCBI GenInfo Identifier: | 462184 |
| NCBI Gene ID: | 6470 |
| NCBI Accession: | P34896.1 |
| UniProt Related Accession: | P34896 |
| Molecular Weight: | |
| NCBI Full Name: | Serine hydroxymethyltransferase, cytosolic |
| NCBI Synonym Full Names: | serine hydroxymethyltransferase 1 |
| NCBI Official Symbol: | SHMT1 |
| NCBI Official Synonym Symbols: | SHMT; CSHMT |
| NCBI Protein Information: | serine hydroxymethyltransferase, cytosolic |
| UniProt Protein Name: | Serine hydroxymethyltransferase, cytosolic |
| UniProt Synonym Protein Names: | Glycine hydroxymethyltransferase; Serine methylase |
| Protein Family: | Serine hydroxymethyltransferase |
| UniProt Gene Name: | SHMT1 |
| UniProt Entry Name: | GLYC_HUMAN |
