Description
| 抗体名: | SHB Antibody (PACO22606) |
| 抗体コード: | PACO22606 |
| サイズ: | 100ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB |
| 推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
| 反応性: | Human |
| 免疫原: | Synthesized peptide derived from C-terminal of human SHB. |
| 憲法: | Liquid |
| ストレージバッファ: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from HuvEc cells, using SHB antibody. |
| バックグラウンド: | Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic-FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells. |
| シノニム: | SH2 domain-containing adapter protein B; SHB; |
| UniProt Protein Function: | SHB: Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic- FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 9p13.2 Cellular Component: cytosol Molecular Function:protein binding; SH3/SH2 adaptor activity Biological Process: signal transduction; vascular endothelial growth factor receptor signaling pathway |
| UniProt Code: | Q15464 |
| NCBI GenInfo Identifier: | 110816415 |
| NCBI Gene ID: | 6461 |
| NCBI Accession: | Q15464.2 |
| UniProt Secondary Accession: | Q15464,Q504U5, Q5VUM8, B9EGM0, D3DRQ5, |
| UniProt Related Accession: | Q15464 |
| Molecular Weight: | 30,703 Da |
| NCBI Full Name: | SH2 domain-containing adapter protein B |
| NCBI Synonym Full Names: | SH2 domain containing adaptor protein B |
| NCBI Official Symbol: | SHB |
| NCBI Official Synonym Symbols: | bA3J10.2 |
| NCBI Protein Information: | SH2 domain-containing adapter protein B |
| UniProt Protein Name: | SH2 domain-containing adapter protein B |
| Protein Family: | SH2 domain-containing adapter protein |
| UniProt Gene Name: | SHB |
| UniProt Entry Name: | SHB_HUMAN |
| Antibodies |
| Anti-SHB Antibody (CAB15318) |
| Phospho-SHB (Y246) Antibody (PACO00266) |
| SHB Antibody (PACO05048) |
| SHB Antibody (PACO05049) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
