Description
| 抗体名: | SH2D2A Antibody (PACO22608) |
| 抗体コード: | PACO22608 |
| サイズ: | 100ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB |
| 推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
| 反応性: | Human |
| 免疫原: | Synthesized peptide derived from internal of human SH2D2A. |
| 憲法: | Liquid |
| ストレージバッファ: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| 精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from HepG2 cells, using SH2D2A antibody. |
| バックグラウンド: | Could be a T-cell-specific adapter protein involved in the control of T-cell activation. May play a role in the CD4-p56-LCK-dependent signal transduction pathway. Could also play an important role in normal and pathological angiogenesis. Could be an adapter protein that facilitates and regulates interaction of KDR with effector proteins important to endothelial cell survival and proliferation. |
| シノニム: | SCAP; SH2 domain containing adapter; SH2 domain protein 2A; SH2 domain-containing 2A; SH22A |
| UniProt Protein Function: | TSAd: an adaptor protein that may facilitate and regulate interaction of KDR with effector proteins important to endothelial cell survival and proliferation. May play a role in the CD4-p56- LCK-dependent signal transduction pathway in T cells. Could also play an important role in normal and pathological angiogenesis. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 1q21 Cellular Component: cytoplasm; cytosol Molecular Function:protein binding; SH3 domain binding; SH3/SH2 adaptor activity Biological Process: angiogenesis; cell differentiation; cell proliferation; positive regulation of signal transduction; signal transduction; vascular endothelial growth factor receptor signaling pathway |
| NCBI Summary: | This gene encodes an adaptor protein thought to function in T-cell signal transduction. A related protein in mouse is responsible for the activation of lymphocyte-specific protein-tyrosine kinase and functions in downstream signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010] |
| UniProt Code: | Q9NP31 |
| NCBI GenInfo Identifier: | 143811460 |
| NCBI Gene ID: | 9047 |
| NCBI Accession: | Q9NP31.3 |
| UniProt Secondary Accession: | Q9NP31,O43817, Q5UBZ1, Q5VZS4, Q5VZS5, Q9UPA7, |
| UniProt Related Accession: | Q9NP31 |
| Molecular Weight: | 40,954 Da |
| NCBI Full Name: | SH2 domain-containing protein 2A |
| NCBI Synonym Full Names: | SH2 domain containing 2A |
| NCBI Official Symbol: | SH2D2A |
| NCBI Official Synonym Symbols: | SCAP; TSAD; VRAP; F2771 |
| NCBI Protein Information: | SH2 domain-containing protein 2A |
| UniProt Protein Name: | SH2 domain-containing protein 2A |
| UniProt Synonym Protein Names: | SH2 domain-containing adapter protein; T cell-specific adapter protein; TSAd; VEGF receptor-associated protein |
| Protein Family: | SH2 domain-containing protein |
| UniProt Gene Name: | SH2D2A |
| UniProt Entry Name: | SH22A_HUMAN |
