Description
| 抗体名: | SF3B6 Antibody (PACO42862) |
| 抗体コード: | PACO42862 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, IHC |
| 推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| 反応性: | Human |
| 免疫原: | Recombinant Human Splicing factor 3B subunit 6 protein (1-125AA) |
| 憲法: | Liquid |
| ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| 精製方法: | >95%, Protein G purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human colon cancer using PACO42862 at dilution of 1:100. |
| バックグラウンド: | Necessary for the splicing of pre-mRNA. Directly contacts the pre-mRNA branch site adenosine for the first catalytic step of splicing. Enters the spliceosome and associates with the pre-mRNA branch site as part of the 17S U2 or, in the case of the minor spliceosome, as part of the 18S U11/U12 snRNP complex, and thus may facilitate the interaction of these snRNP with the branch sites of U2 and U12 respectively. |
| シノニム: | Splicing factor 3B subunit 6 (Pre-mRNA branch site protein p14) (SF3b 14 kDa subunit) (SF3B14a) (Spliceosome-associated protein, 14-kDa) (Splicing factor 3b, subunit 6, 14kDa), SF3B6, SAP14 SF3B14 SF3B14A |
| UniProt Protein Function: | SF3B6: subunit of the splicing factor SF3B. Necessary for the splicing of pre-mRNA. Directly contacts the pre-mRNA branch site adenosine for the first catalytic step of splicing. Enters the spliceosome and associates with the pre-mRNA branch site as part of the 17S U2 or, in the case of the minor spliceosome, as part of the 18S U11/U12 snRNP complex, and thus may facilitate the interaction of these snRNP with the branch sites of U2 and U12 respectively. |
| UniProt Protein Details: | Protein type:Spliceosome; RNA-binding; RNA splicing Chromosomal Location of Human Ortholog: 2p23 Cellular Component: nucleoplasm; snRNP U2; U12-dependent spliceosome Molecular Function:nucleotide binding Biological Process: blastocyst formation; gene expression; nuclear mRNA splicing, via spliceosome; RNA splicing |
| NCBI Summary: | This gene encodes a 14 kDa protein subunit of the splicing factor 3b complex. Splicing factor 3b associates with both the U2 and U11/U12 small nuclear ribonucleoprotein complexes (U2 snRNP) of spliceosomes. This 14 kDa protein interacts directly with subunit 1 of the splicing factor 3b complex. This 14 kDa protein also interacts directly with the adenosine that carries out the first transesterification step of splicing at the pre-mRNA branch site. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9Y3B4 |
| NCBI GenInfo Identifier: | 7706326 |
| NCBI Gene ID: | 51639 |
| NCBI Accession: | NP_057131.1 |
| UniProt Secondary Accession: | Q9Y3B4,Q53TM1, |
| UniProt Related Accession: | Q9Y3B4 |
| Molecular Weight: | 14,585 Da |
| NCBI Full Name: | splicing factor 3B subunit 6 |
| NCBI Synonym Full Names: | splicing factor 3b subunit 6 |
| NCBI Official Symbol: | SF3B6 |
| NCBI Official Synonym Symbols: | P14; Ht006; SAP14; SAP14a; SF3B14; CGI-110; HSPC175; SF3B14a |
| NCBI Protein Information: | splicing factor 3B subunit 6 |
| UniProt Protein Name: | Splicing factor 3B subunit 6 |
| UniProt Synonym Protein Names: | Pre-mRNA branch site protein p14; SF3b 14 kDa subunit; SF3B14a; Spliceosome-associated protein, 14-kDa; Splicing factor 3b, subunit 6, 14kDa |
| Protein Family: | Splicing factor |
| UniProt Gene Name: | SF3B6 |
| UniProt Entry Name: | SF3B6_HUMAN |
