Description
| 抗体名: | SF3B2 Antibody (PACO42984) |
| 抗体コード: | PACO42984 |
| サイズ: | 50ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, IHC |
| 推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| 反応性: | Human |
| 免疫原: | Recombinant Human Splicing factor 3B subunit 2 protein (616-895AA) |
| 憲法: | Liquid |
| ストレージバッファ: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 精製方法: | Antigen Affinity Purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human colon cancer using PACO42984 at dilution of 1:100. |
| バックグラウンド: | Subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron. |
| シノニム: | Splicing factor 3B subunit 2 (Pre-mRNA-splicing factor SF3b 145 kDa subunit) (SF3b145) (Spliceosome-associated protein 145) (SAP 145), SF3B2, SAP145 |
| UniProt Protein Function: | SF3B2: subunit of the splicing factor SF3B required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (bps) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex. Belongs also to the minor U12-dependent spliceosome, which is involved in the splicing of rare class of nuclear pre-mRNA intron. |
| UniProt Protein Details: | Protein type:RNA-binding; RNA splicing; Spliceosome; RNA processing Chromosomal Location of Human Ortholog: 11q13.1 Cellular Component: nucleoplasm; snRNP U2; spliceosome; U12-dependent spliceosome Molecular Function:protein binding Biological Process: mRNA processing; nuclear mRNA splicing, via spliceosome; RNA splicing |
| NCBI Summary: | This gene encodes subunit 2 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence-independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. Subunit 2 associates with pre-mRNA upstream of the branch site at the anchoring site. Subunit 2 also interacts directly with subunit 4 of the splicing factor 3b complex. Subunit 2 is a highly hydrophilic protein with a proline-rich N-terminus and a glutamate-rich stretch in the C-terminus. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q13435 |
| NCBI GenInfo Identifier: | 296452908 |
| NCBI Gene ID: | 10992 |
| NCBI Accession: | Q13435.2 |
| UniProt Secondary Accession: | Q13435,Q7L4T5, Q7Z627, Q969K1, Q96CM6, Q9BWD2, A8K485 B4DT19, |
| UniProt Related Accession: | Q13435 |
| Molecular Weight: | 100,228 Da |
| NCBI Full Name: | Splicing factor 3B subunit 2 |
| NCBI Synonym Full Names: | splicing factor 3b subunit 2 |
| NCBI Official Symbol: | SF3B2 |
| NCBI Official Synonym Symbols: | Cus1; SF3b1; SAP145; SF3B145; SF3b150 |
| NCBI Protein Information: | splicing factor 3B subunit 2 |
| UniProt Protein Name: | Splicing factor 3B subunit 2 |
| UniProt Synonym Protein Names: | Pre-mRNA-splicing factor SF3b 145 kDa subunit; SF3b145; SF3b150; Spliceosome-associated protein 145; SAP 145 |
| Protein Family: | Splicing factor |
| UniProt Gene Name: | SF3B2 |
| UniProt Entry Name: | SF3B2_HUMAN |
