The SARAF Antibody (PAC039802) is a polyclonal antibody designed for research involving SARAF, a calcium-regulating protein involved in store-operated calcium entry (SOCE). The antibody, raised in rabbits, is highly reactive with human samples and is validated for use in various applications such as Western blot and immunofluorescence. It binds specifically to the SARAF protein, enabling accurate detection and analysis in a variety of cell types.SARAF is a key regulator of SOCE, a vital process in calcium signaling that plays a crucial role in immune responses, cell proliferation, and gene expression. Dysregulation of SOCE has been implicated in various diseases, including immune disorders, neurodegenerative diseases, and cancer.
Understanding the role of SARAF in calcium homeostasis and immune function is essential for developing therapeutic interventions targeting these conditions.The SARAF Antibody is a valuable tool for researchers studying calcium signaling pathways, immune responses, and disease mechanisms. Its specificity and sensitivity make it an ideal choice for investigations in cell biology, immunology, and oncology, providing insights into the intricate roles of SARAF in health and disease.
Antibody Name:
SARAF Antibody (PACO39802)
Antibody SKU:
PACO39802
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA
Recommended Dilutions:
Species Reactivity:
Human
Immunogen:
Recombinant Human Store-operated calcium entry-associated regulatory factor protein (195-339AA)
Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)-dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions.
TMEM66: Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)- dependent SOCE activity: possibly act by facilitating the deoligomerization of STIM to efficiently turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the cell with excessive Ca(2+) ions. Belongs to the SARAF family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integralChromosomal Location of Human Ortholog: 8p12Cellular Component: integral to endoplasmic reticulum membraneMolecular Function: protein binding
