Description
| 抗体名: | SAP18 Antibody (PACO12024) |
| 抗体コード: | PACO12024 |
| サイズ: | 50ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB, IHC, IF |
| 推奨される希釈: | |
| 反応性: | Human, Mouse, Rat |
| 免疫原: | Human SAP18 |
| 憲法: | Liquid |
| ストレージバッファ: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| 精製方法: | Antigen Affinity purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
| シノニム: | Sin3A-associated protein, 18kDa;SAP18;2HOR0202;MGC27131;SAP18P ; |
| UniProt Protein Function: | SAP18: Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins. Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Belongs to the SAP18 family. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 13q12.11 Cellular Component: nucleoplasm; histone deacetylase complex; cytoplasm; nuclear speck Molecular Function:protein binding; transcription corepressor activity Biological Process: regulation of transcription from RNA polymerase II promoter; establishment and/or maintenance of chromatin architecture; negative regulation of nuclear mRNA splicing, via spliceosome; transcription, DNA-dependent; negative regulation of gene expression, epigenetic; positive regulation of apoptosis; RNA splicing; gene expression; mRNA processing; regulation of gene expression, epigenetic; regulation of alternative nuclear mRNA splicing, via spliceosome |
| NCBI Summary: | Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter. A pseudogene has been identified on chromosome 2. [provided by RefSeq, Dec 2008] |
| UniProt Code: | O00422 |
| NCBI GenInfo Identifier: | 6831678 |
| NCBI Gene ID: | 10284 |
| NCBI Accession: | O00422.1 |
| UniProt Related Accession: | O00422 |
| Molecular Weight: | |
| NCBI Full Name: | Histone deacetylase complex subunit SAP18 |
| NCBI Synonym Full Names: | Sin3A associated protein 18 |
| NCBI Official Symbol: | SAP18 |
| NCBI Official Synonym Symbols: | SAP18P; 2HOR0202 |
| NCBI Protein Information: | histone deacetylase complex subunit SAP18 |
| UniProt Protein Name: | Histone deacetylase complex subunit SAP18 |
| UniProt Synonym Protein Names: | 18 kDa Sin3-associated polypeptide; 2HOR0202; Cell growth-inhibiting gene 38 protein; Sin3-associated polypeptide p18 |
| Protein Family: | Zinc finger A20 domain-containing stress-associated protein |
| UniProt Gene Name: | SAP18 |
| UniProt Entry Name: | SAP18_HUMAN |
