Description
| 抗体名: | RXRG Antibody, HRP conjugated (PACO47627) |
| 抗体コード: | PACO47627 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA |
| 推奨される希釈: | |
| 反応性: | Human |
| 免疫原: | Recombinant Human Retinoic acid, receptor RXR-γ protein (13-133AA) |
| 憲法: | Liquid |
| ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| 精製方法: | >95%, Protein G purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | HRP |
| バックグラウンド: | Receptor for retinoic acid, Retinoic acid, receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid, response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid, (By similarity). |
| シノニム: | Retinoic acid, receptor RXR-γ (Nuclear receptor subfamily 2 group B member 3) (Retinoid X receptor gamma), RXRG, NR2B3 |
| UniProt Protein Function: | RXRG: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. Homodimer. Heterodimer with a RAR molecule. Binds DNA preferentially as a RAR/RXR heterodimer. Belongs to the nuclear hormone receptor family. NR2 subfamily. |
| UniProt Protein Details: | Protein type:DNA-binding; Nuclear receptor Chromosomal Location of Human Ortholog: 1q22-q23 Cellular Component: nucleoplasm Molecular Function:protein binding; zinc ion binding; retinoid-X receptor activity; steroid hormone receptor activity Biological Process: retinoic acid receptor signaling pathway; neuron differentiation; transcription initiation from RNA polymerase II promoter; skeletal muscle development; response to retinoic acid; regulation of myelination; heart development; steroid hormone mediated signaling; gene expression; transmembrane transport; protein homotetramerization; peripheral nervous system development |
| NCBI Summary: | This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms dimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2010] |
| UniProt Code: | P48443 |
| NCBI GenInfo Identifier: | 1350913 |
| NCBI Gene ID: | 6258 |
| NCBI Accession: | P48443.1 |
| UniProt Secondary Accession: | P48443,Q6IBU7, A6NIP1, |
| UniProt Related Accession: | P48443 |
| Molecular Weight: | 50,871 Da |
| NCBI Full Name: | Retinoic acid receptor RXR-gamma |
| NCBI Synonym Full Names: | retinoid X receptor, gamma |
| NCBI Official Symbol: | RXRG |
| NCBI Official Synonym Symbols: | RXRC; NR2B3 |
| NCBI Protein Information: | retinoic acid receptor RXR-gamma; nuclear receptor subfamily 2 group B member 3 |
| UniProt Protein Name: | Retinoic acid receptor RXR-gamma |
| UniProt Synonym Protein Names: | Nuclear receptor subfamily 2 group B member 3; Retinoid X receptor gamma |
| UniProt Gene Name: | RXRG |
| UniProt Entry Name: | RXRG_HUMAN |
