Description
RTN2 Antibody (PACO11980)
The RTN2 Polyclonal Antibody (PAC011980) is a valuable tool for researchers studying the reticulon protein RTN2, which plays a key role in regulating endoplasmic reticulum structure and function. This antibody, raised in rabbits, has been validated for use in various applications, including Western blot and immunofluorescence.RTN2 is involved in processes such as membrane trafficking, neuronal development, and neurodegenerative diseases. Dysregulation of RTN2 has been linked to conditions such as Alzheimer's disease and Parkinson's disease, making it a promising target for therapeutic interventions.
By detecting and analyzing RTN2 expression and localization in cells, the RTN2 Polyclonal Antibody enables researchers to further understand the role of this protein in cellular physiology and disease pathology. It is an essential tool for studies in neuroscience, cell biology, and neurodegenerative disorders.
| Antibody Name: | RTN2 Antibody (PACO11980) |
| Antibody SKU: | PACO11980 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Human RTN2 |
| Form: | Liquid |
| Storage Buffer: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| Purification Method: | Affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Synonyms: | reticulon 2;RTN2;NSP2;NSPL1 ; |
| UniProt Protein Function: | RTN2: Defects in RTN2 are the cause of spastic paraplegia autosomal dominant type 12 (SPG12). A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Endoplasmic reticulum; Membrane protein, integral Chromosomal Location of Human Ortholog: 19q13.32 Cellular Component: endoplasmic reticulum; T-tubule; integral to endoplasmic reticulum membrane Molecular Function:protein binding Biological Process: intracellular protein transport across a membrane; regulation of glucose import Disease: Spastic Paraplegia 12, Autosomal Dominant |
| NCBI Summary: | This gene belongs to the family of reticulon encoding genes. Reticulons are necessary for proper generation of tubular endoplasmic reticulum and likely play a role in intracellular vesicular transport. Alternatively spliced transcript variants encoding different isoforms have been identified. Mutations at this locus have been associated with autosomal dominant spastic paraplegia-12. [provided by RefSeq, Apr 2012] |
| UniProt Code: | O75298 |
| NCBI GenInfo Identifier: | 13633878 |
| NCBI Gene ID: | 6253 |
| NCBI Accession: | O75298.1 |
| UniProt Secondary Accession: | O75298,O60509, Q7RTM6, Q7RTN1, Q7RTN2, |
| UniProt Related Accession: | O75298 |
| Molecular Weight: | 545 |
| NCBI Full Name: | Reticulon-2 |
| NCBI Synonym Full Names: | reticulon 2 |
| NCBI Official Symbol: | RTN2 |
| NCBI Official Synonym Symbols: | NSP2; NSPL1; NSPLI; SPG12 |
| NCBI Protein Information: | reticulon-2; NSP-like protein 1; NSP-like protein I; neuroendocrine-specific protein-like I |
| UniProt Protein Name: | Reticulon-2 |
| UniProt Synonym Protein Names: | Neuroendocrine-specific protein-like 1; NSP-like protein 1; Neuroendocrine-specific protein-like I; NSP-like protein I; NSPLI |
| Protein Family: | Reticulon |
| UniProt Gene Name: | RTN2 |
| UniProt Entry Name: | RTN2_HUMAN |
