| UniProt Protein Function: | RPH3AL: Rab GTPase effector involved in the late steps of regulated exocytosis, both in endocrine and exocrine cells. Acts as a potential RAB3B effector protein in epithelial cells. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 17p13.3 Cellular Component: cytoplasm; plasma membrane Molecular Function:calcium ion binding; calcium-dependent phospholipid binding; clathrin binding; cytoskeletal protein binding; protein binding; syntaxin binding Biological Process: calcium ion-dependent exocytosis of neurotransmitter; exocytosis; regulation of calcium ion-dependent exocytosis; vesicle fusion |
| NCBI Summary: | The protein encoded by this gene plays a direct regulatory role in calcium-ion-dependent exocytosis in both endocrine and exocrine cells and plays a key role in insulin secretion by pancreatic cells. This gene is likely a tumor suppressor. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jun 2010] |
| UniProt Code: | Q9UNE2 |
| NCBI GenInfo Identifier: | 74735140 |
| NCBI Gene ID: | 9501 |
| NCBI Accession: | Q9UNE2.1 |
| UniProt Secondary Accession: | Q9UNE2,Q9BSB3, D3DTG7, |
| UniProt Related Accession: | Q9UNE2 |
| Molecular Weight: | 31,190 Da |
| NCBI Full Name: | Rab effector Noc2 |
| NCBI Synonym Full Names: | rabphilin 3A-like (without C2 domains) |
| NCBI Official Symbol: | RPH3AL |
| NCBI Official Synonym Symbols: | NOC2 |
| NCBI Protein Information: | rab effector Noc2 |
| UniProt Protein Name: | Rab effector Noc2 |
| UniProt Synonym Protein Names: | No C2 domains protein; Rabphilin-3A-like protein |
| Protein Family: | Rab effector |
| UniProt Gene Name: | RPH3AL |
| UniProt Entry Name: | RPH3L_HUMAN |
