Description
| 抗体名: | RGS5 Antibody (PACO05542) |
| 抗体コード: | PACO05542 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB, IHC |
| 推奨される希釈: | ELISA:1:20000, WB:1:500-1:2000, IHC:1:100-1:300 |
| 反応性: | Human, Mouse, Rat |
| 免疫原: | Synthesized peptide derived from the Internal region of human RGS5. |
| 憲法: | Liquid |
| ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| 精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
| シノニム: | RGS5; Regulator of G-protein signaling 5; RGS5 |
| UniProt Protein Function: | RGS5: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:GAPs, RGS; GAPs Chromosomal Location of Human Ortholog: 1q23.1 Cellular Component: cytoplasm; plasma membrane Molecular Function:GTPase activator activity Biological Process: regulation of G-protein coupled receptor protein signaling pathway Disease: Hypertension, Essential |
| NCBI Summary: | This gene encodes a member of the regulators of G protein signaling (RGS) family. The RGS proteins are signal transduction molecules which are involved in the regulation of heterotrimeric G proteins by acting as GTPase activators. This gene is a hypoxia-inducible factor-1 dependent, hypoxia-induced gene which is involved in the induction of endothelial apoptosis. This gene is also one of three genes on chromosome 1q contributing to elevated blood pressure. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Dec 2011] |
| UniProt Code: | O15539 |
| NCBI GenInfo Identifier: | 3914625 |
| NCBI Gene ID: | 8490 |
| NCBI Accession: | O15539.1 |
| UniProt Secondary Accession: | O15539,Q53XA9, Q599J0, E9PMP5, |
| UniProt Related Accession: | O15539 |
| Molecular Weight: | 21,402 Da |
| NCBI Full Name: | Regulator of G-protein signaling 5 |
| NCBI Synonym Full Names: | regulator of G-protein signaling 5 |
| NCBI Official Symbol: | RGS5 |
| NCBI Official Synonym Symbols: | MST092; MST106; MST129; MSTP032; MSTP092; MSTP106; MSTP129 |
| NCBI Protein Information: | regulator of G-protein signaling 5 |
| UniProt Protein Name: | Regulator of G-protein signaling 5 |
| Protein Family: | Regulator of G-protein signaling |
| UniProt Gene Name: | RGS5 |
| UniProt Entry Name: | RGS5_HUMAN |
