Description
| 抗体名: | RGS10 Antibody (PACO11816) |
| 抗体コード: | PACO11816 |
| サイズ: | 50ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB |
| 推奨される希釈: | |
| 反応性: | Human, Mouse, Rat |
| 免疫原: | Human RGS10 |
| 憲法: | Liquid |
| ストレージバッファ: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| 精製方法: | Antigen Affinity Purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
| シノニム: | regulator of G-protein signaling 10; |
| UniProt Protein Function: | RGS10: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Associates specifically with the activated forms of the G protein subunits G(i)-alpha and G(z)- alpha but fails to interact with the structurally and functionally distinct G(s)-alpha subunit. Activity on G(z)-alpha is inhibited by palmitoylation of the G-protein. |
| UniProt Protein Details: | Protein type:GAPs, RGS; GAPs Chromosomal Location of Human Ortholog: 10q25 Cellular Component: cell soma; cytoplasm; dendritic spine; plasma membrane; nerve terminal; nucleus Molecular Function:GTPase activator activity Biological Process: positive regulation of GTPase activity |
| NCBI Summary: | Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 10 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. This protein associates specifically with the activated forms of the two related G-protein subunits, G-alphai3 and G-alphaz but fails to interact with the structurally and functionally distinct G-alpha subunits. Regulator of G protein signaling 10 protein is localized in the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O43665 |
| NCBI GenInfo Identifier: | 52694755 |
| NCBI Gene ID: | 6001 |
| NCBI Accession: | NP_001005339.1 |
| UniProt Secondary Accession: | O43665,Q6IAZ6, Q96GN0, A8K408, B1AMR8, |
| UniProt Related Accession: | O43665 |
| Molecular Weight: | 20 KD |
| NCBI Full Name: | regulator of G-protein signaling 10 isoform a |
| NCBI Synonym Full Names: | regulator of G-protein signaling 10 |
| NCBI Official Symbol: | RGS10 |
| NCBI Protein Information: | regulator of G-protein signaling 10; regulator of G-protein signalling 10 |
| UniProt Protein Name: | Regulator of G-protein signaling 10 |
| Protein Family: | Regulator of G-protein signaling |
| UniProt Gene Name: | RGS10 |
| UniProt Entry Name: | RGS10_HUMAN |
