| UniProt Protein Function: | RGN: Gluconolactonase with low activity towards other sugar lactones, including gulonolactone and galactonolactone. Can also hydrolyze diisopropyl phosphorofluoridate and phenylacetate (in vitro). Calcium-binding protein. Modulates Ca(2+) signaling, and Ca(2+)-dependent cellular processes and enzyme activities. Belongs to the SMP-30/CGR1 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.1.1.17 Chromosomal Location of Human Ortholog: Xp11.3 Cellular Component: nucleoplasm; cytoplasm; nucleus Molecular Function:zinc ion binding; gluconolactonase activity; calcium ion binding; enzyme regulator activity Biological Process: cellular calcium ion homeostasis; L-ascorbic acid biosynthetic process; positive regulation of ATPase activity; regulation of calcium-mediated signaling |
| NCBI Summary: | The protein encoded by this gene is a highly conserved, calcium-binding protein, that is preferentially expressed in the liver and kidney. It may have an important role in calcium homeostasis. Studies in rat indicate that this protein may also play a role in aging, as it shows age-associated down-regulation. This gene is part of a gene cluster on chromosome Xp11.3-Xp11.23. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013] |
| UniProt Code: | Q15493 |
| NCBI GenInfo Identifier: | 3334328 |
| NCBI Gene ID: | 9104 |
| NCBI Accession: | Q15493.1 |
| UniProt Related Accession: | Q15493 |
| Molecular Weight: | 33 kDa |
| NCBI Full Name: | Regucalcin |
| NCBI Synonym Full Names: | regucalcin |
| NCBI Official Symbol: | RGN |
| NCBI Official Synonym Symbols: | RC; GNL; SMP30; HEL-S-41 |
| NCBI Protein Information: | regucalcin |
| UniProt Protein Name: | Regucalcin |
| UniProt Synonym Protein Names: | Gluconolactonase (EC:3.1.1.17); GNL; Senescence marker protein 30; SMP-30 |
| Protein Family: | Regucalcin |
| UniProt Gene Name: | RGN |
| UniProt Entry Name: | RGN_HUMAN |
