Description
| Product Name: | Recombinant Mouse TNFSF12/TWEAK Protein |
| SKU: | RPCB1730 |
| Size: | 50µg |
| Tag: | C-raFc |
| Reactivity: | Mouse |
| Expression Host: | HEK293 Cells |
| Protein Description: | High quality, high purity and low endotoxin recombinant Recombinant Mouse TNFSF12/TWEAK Protein , tested reactivity in HEK293 Cells and has been validated in SDS-PAGE.100% guaranteed. |
| Endotoxin: | <1EU/μg |
| Purity: | > 90% by SDS-PAGE. |
| Formulation: | Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. |
| Gene ID: | 21944 |
TNFSF12 is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. It is a ligand for the FN14/TWEAKR receptor. TNFSF12 has overlapping signaling functions with TNF, but displays a much wider tissue distribution. It can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. It is also found that TNFSF12 promotes proliferation and migration of endothelial cells, and thus acts as a regulator of angiogenesis. TNFSF12 also is a weak inducer of apoptosis in some cell types and mediates NF-kappa-B activation.
| Storage: | Store at -20℃.Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt.After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week. |
| Reconstitution: | Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid vortex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles. |
| Swiss-Prot: | O54907 |
 | Recombinant Mouse TNFSF12/TWEAK Protein was determined by SDS-PAGE with Coomassie Blue, showing bands at 45 kDa. |
 | Recombinant Mouse TNFSF12 promotes the proliferation of human umbilical vein endothelial cells (HUVEC). The ED₅₀ for this effect is typically 10-50 ng/mL. |
