Description
| Product Name: | Recombinant Mouse NRG-1 Protein (His Tag) |
| SKU: | RPES8457 |
| Size: | 20μg |
| Tag: | C-His |
| Reactivity: | Mouse |
| Expression Host: | Mammalian |
| Accession: | Q6DR98 |
| Sequence: | Ser177-Gln237 |
| Calculated Molecular Weight: | 6.6 kDa |
| Observed Molecular Weight: | 50 kDa |
| Synonyms: | Acetylcholine receptor-inducing activity, Acetylcholine receptor-inducing activity, CHICK, homolog of, ARIA, Breast cancer cell differentiation factor p45, GGF, GGF2, Glial growth factor, Heregulin, heregulin, alpha (45kD, ERBB2 p185-activator), HGL, HRG, HRG1, HRGA, MST131, NDF, Neu differentiation factor, Neuregulin 1, neuregulin 1 type IV beta 1a, neuregulin 1 type IV beta 3, Neuregulin-1, NRG 1, nrg1, NRG1-IT2, NRG1_HUMAN |
| Endotoxin: | < 1.0 EU/mg of the protein as determined by the LAL method |
| Purity: | > 90% as determined by reducing SDS-PAGE. |
Neuregulin 1 or NRG1 is one of four proteins in the neuregulin family that act on the EGFR family of receptors. This growth factor was originally identified as a 44-kD glycoprotein that interacts with the NEU / ERBB2 receptor tyrosine kinase to increase its phosphorylation on tyrosine residues. NRG1 is a trophic factor that has been implicated in neural development, neurotransmission, and synaptic plasticity. NRG1 has multiple isoforms that are generated by the usage of different promoters and alternative splicing of a single gene. Neuregulin 1 (NRG1) is essential for the development and function of multiple organ systems, and its dysregulation has been linked to diseases such as cancer and schizophrenia. NRG1 is a schizophrenia candidate gene and plays an important role in brain development and neural function. Schizophrenia is a complex disorder, with etiology likely due to epistasis.
| Bio-activity: | Not validated for activity |
| Formulation: | Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol. |
| Reconstitution: | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis. |
| Storage: | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
