Description
| Product Name: | Recombinant Mouse CD40/TNFRSF5 Protein (His Tag) |
| SKU: | RPES8497 |
| Size: | 20μg |
| Tag: | C-His |
| Reactivity: | Mouse |
| Expression Host: | Mammalian |
| Accession: | P27512 |
| Sequence: | Leu20-Arg193 |
| Calculated Molecular Weight: | 19 kDa |
| Observed Molecular Weight: | 30 kDa |
| Synonyms: | IMD, B-cell surface antigen CD, Tumor necrosis factor receptor superfamily member, HIGM, Tnfrsf, HIGM1, I326936, IGM, IMD3, p50, T-BAM, TRAP, Bp50, CD40, Tnfrsf5, Tumor necrosis factor receptor superfamily member 5, B-cell surface antigen CD40, CD40L receptor, gp39 R, TNFRSF5, CD40 (protein), CD40 molecule, CDW40 |
| Endotoxin: | < 1.0 EU/mg of the protein as determined by the LAL method |
| Purity: | > 90% as determined by reducing SDS-PAGE. |
CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily which are single transmembrane-spanning glycoproteins. CD40 protein plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 protein is expressed in B cells, dendritic cells, macrophages, endothelial cells, and several tumor cell lines. Defects in CD40 result in hyper-IgM immunodeficiency type 3 (HIGM3). In addition, CD40/CD40L interaction is found to be necessary for amyloid-beta-induced microglial activation, and thus is thoμght to be an early event in Alzheimer disease pathogenesis.
| Bio-activity: | Not validated for activity |
| Formulation: | Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol. |
| Reconstitution: | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis. |
| Storage: | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
