Description
| Product Name: | Recombinant Human MICB Protein (Fc Tag) |
| SKU: | RPES8289 |
| Size: | 20μg |
| Tag: | C-Fc |
| Reactivity: | Human |
| Expression Host: | Mammalian |
| Accession: | Q29980 |
| Sequence: | Ala23-Gly298 |
| Calculated Molecular Weight: | 55.2 kDa |
| Observed Molecular Weight: | 60-80 kDa |
| Synonyms: | MHC class I chain-related protein A, MHC class I chain-related protein B, MHC class I polypeptide related sequence A, MHC class I polypeptide related sequence B, MHC class I polypeptide-related sequence A, MIC-A, micA, MICA_HUMAN, MICB |
| Endotoxin: | < 1.0 EU/mg of the protein as determined by the LAL method |
| Purity: | > 90% as determined by reducing SDS-PAGE. |
This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules, however, it does not associate with an beta-2-microglobulin or bind peptides. Alternative splicing results in multiple transcript variants.
| Bio-activity: | Not validated for activity |
| Formulation: | Lyophilized from a 0.2 μm filtered solution in PBS with 5% Trehalose and 5% Mannitol. |
| Reconstitution: | It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis. |
| Storage: | Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months. |
| Shipping: | This product is provided as lyophilized powder which is shipped with ice packs. |
