Description
| Product Name: | Recombinant Human KLRG1/CLEC15A/CD369 Protein |
| SKU: | RPCB1050 |
| Size: | 10µg |
| Tag: | N-Rabbit Fc |
| Reactivity: | Human |
| Expression Host: | HEK293 cells |
| Protein Description: | High quality, high purity and low endotoxin recombinant Recombinant Human KLRG1/CLEC15A/CD369 Protein , tested reactivity in HEK293 cells and has been validated in SDS-PAGE.100% guaranteed. |
| Endotoxin: | <0.1EU/μg |
| Purity: | > 95% by SDS-PAGE. |
| Formulation: | Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. |
| Gene ID: | 10219 |
KLRG1 (killer cell lectin?like receptor G1), also called MAFA (mast cell function associated), is an inhibitory type II transmembrane glycoprotein of the C?type lectin family, designated CLEC15A.Within the ECD, Human KLRG1 shares 57% and 80% aa sequence identity with mouse and rat KLRG1, respectively.KLRG1 is expressed on subpopulations of CD8+, CD4+, regulatory, and gamma/delta T cells as well as on NK cells. KLRG1 is expressed on T cells found in cord blood, but it is down?regulated postnatally and is subsequently re?expressed on antigen?exposed T cells. It is expressed by a greater proportion of CD8+ T cells in the elderly and by virus?specific CD8+ T cells during chronic virus infection. KLRG1 binds to E-, N-, and R-Cadherins, triggering ITIM?dependent KLRG1 signaling and inhibition of T cell activation. The response is bi?directional, as KLRG1 binding to E?Cadherin on dendritic cells (DC) can induce an anti?inflammatory DC phenotype (increased IL?10 production and decreased IL?6 and TNF? alpha production).
| Storage: | Store at -20℃.Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt.After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week. |
| Reconstitution: | Centrifuge the vial before opening. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. Avoid vortex or vigorously pipetting the protein. For long term storage, it is recommended to add a carrier protein or stablizer (e.g. 0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose), and aliquot the reconstituted protein solution to minimize free-thaw cycles. |
| Swiss-Prot: | Q96E93 |
 | Recombinant Human KLRG1/CLEC15A/CD369 Protein was determined by SDS-PAGE with Coomassie Blue, showing a band at kDa. |
