DNMT3A, as de novo DNA methyltransferase, is essential for regulating gene expression through cellular development and differentiation.IT Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development .It modifies DNA in a non-processive manner and also methylates non-CpG sites . The functions of DNMT3A rely on its oligomeric states and allosteric regulations between its catalytic domain and binding partners. DNMT3A variants are present in elderly healthy individuals and patients with AML in complete remission, which suggests that DNMT3A mutations may contribute to pre-leukemic clonal hematopoiesis.
