Description
| Product Name: | Recombinant Human Asparaginyl endopeptidase/Legumain/LGMN Protein |
| SKU: | RPCB2007 |
| Size: | 50µg |
| Tag: | C-His |
| Reactivity: | Human |
| Expression Host: | Mammalian expression system |
| Protein Description: | High quality, high purity and low endotoxin recombinant Recombinant Human Asparaginyl endopeptidase/Legumain/LGMN Protein , tested reactivity in HEK293 cells and has been validated in SDS-PAGE.100% guaranteed. |
| Endotoxin: | < 1.0 EU/μg of the protein by LAL method. |
| Purity: | > 95% by SDS-PAGE. |
| Formulation: | Supplied as a 0.2 μm filtered solution of 20 mM Tris-HCl, 150 mM NaCl, 10% Glycerol, pH 8.0. |
| Gene ID: | 5641 |
Legumain is a lysosomal cysteine protease which is a member of the peptidase C13 family. Though it is found in many tissues, it is highly expressed in the kidney, heart, and placenta. Legumain has a strict specificity for hydrolysis of asparaginyl bonds and can also cleave aspartyl bonds slowly, especially under acidic conditions. Over-expression Legumain in tumors is significant for invasion and metastasis. In addition, Legumain may be involved in the processing of proteins for MHC class II antigen presentation in the lysosomal/endosomal system and negative regulation of neuron apoptosis.
| Storage: | Store at -70℃. This product is stable at ≤ -70℃ for up to 1 year from the date of receipt. For optimal storage, aliquot into smaller quantities after centrifugation and store at recommended temperature. Avoid repeated freeze-thaw cycles. |
| Swiss-Prot: | AAH03061.1 |
 | Recombinant Human Asparaginyl endopeptidase/Legumain Protein was determined by SDS-PAGE with Coomassie Blue, showing a band at 55-60 kDa. |
