The RBPJL Polyclonal Antibody (PACO54574) is a crucial tool for researchers studying RBPJL, a transcription factor involved in critical biological processes such as development and cell differentiation. This antibody, generated in rabbits, exhibits a high level of reactivity with human samples and has been validated for Western blot applications. By targeting the RBPJL protein, this antibody allows for precise detection and analysis in a variety of cell types, making it an essential tool for investigations in developmental biology and cancer research.
RBPJL, also known as recombination signal binding protein for immunoglobulin kappa J region-like, plays a significant role in regulating gene expression and controlling cellular processes. Its involvement in key pathways makes it a valuable target for research into diseases such as cancer and developmental disorders. Understanding the function of RBPJL is essential for developing targeted therapies and advancing our knowledge of biological processes.
Western Blot. Positive WB detected in: HEK293 whole cell lysate. All lanes: RBPJL antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 57 kDa. Observed band size: 57 kDa.
Immunohistochemistry of paraffin-embedded human pancreatic cancer using PACO54574 at dilution of 1:100.
Background:
Putative transcription factor, which cooperates with EBNA2 to activate transcription.
Synonyms:
Recombining binding protein suppressor of hairless-like protein (Transcription factor RBP-L), RBPJL, RBPL RBPSUHL
UniProt Protein Function:
RBPJL: Putative transcription factor, which cooperates with EBNA2 to activate transcription. Belongs to the Su(H) family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Transcription factor; DNA-bindingChromosomal Location of Human Ortholog: 20q13.12Molecular Function: transcription factor activityBiological Process: signal transduction
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the suppressor of hairless protein family. A similar protein in mouse is a transcription factor that binds to DNA sequences almost identical to that bound by the Notch receptor signaling pathway transcription factor recombining binding protein J. The mouse protein has been shown to activate transcription in concert with Epstein-Barr virus nuclear antigen-2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
