Description
| Product Name: | Rat OSM Recombinant Protein |
| Product Code: | RPPB0827 |
| Size: | 10µg |
| Species: | Rat |
| Target: | OSM |
| Synonyms: | Oncostatin-M, OSM, OncoM. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | OSM protein was lyophilized from a 0.2�m filtered concentrated solution in 1xPBS, pH 7.4. |
| Solubility: | It is recommended to reconstitute the lyophilized Oncostatin M in sterile 18M?-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized Oncostatin M although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Oncostatin should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | KRGCSSSSPK LLSQLKSQAN ITGNTASLLE PYILHQNLNT LTLRAACTEH PVAFPSEDML RQLSKPDFLS TVHATLGRVW HQLGAFRQQF PKIQDFPELE RARQNIQGIR NNVYCMARLL HPPLEIPEPT QADSGTSRPT TTAPGIFQIK IDSCRFLWGY HRFMGSVGRV FEEWGDGSRR SR RHSPLWAW LKGDHRIRPS RSSQSAMLRS LVPR |
| Biological Activity: | The ED50 as determined by the dose-dependent stimulation of the proliferation of rat C6 cells is < 5.0 �g/ml, corresponding to a specific activity of > 200 units/mg. |
Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. This gene encodes a growth regulator which inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells.
OSM Rat Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 214 amino acids and having a molecular mass of 24.3kDa.The OSM is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Growth regulator. Inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. Uses only type II OSM receptor (heterodimers composed of OSMR and IL6ST). Involved in the maturation of fetal hepatocytes, thereby promoting liver development and regeneration. |
| NCBI Summary: | mouse homolog is a cytokine and an immediate early gene [RGD, Feb 2006] |
| UniProt Code: | Q65Z15 |
| NCBI GenInfo Identifier: | 81890504 |
| NCBI Gene ID: | 289747 |
| NCBI Accession: | Q65Z15.1 |
| UniProt Related Accession: | Q65Z15 |
| Molecular Weight: | 27,106 Da |
| NCBI Full Name: | Oncostatin-M |
| NCBI Synonym Full Names: | oncostatin M |
| NCBI Official Symbol: | Osm�� |
| NCBI Protein Information: | oncostatin-M |
| UniProt Protein Name: | Oncostatin-M |
| Protein Family: | Oncostatin |
| UniProt Gene Name: | Osm�� |
| UniProt Entry Name: | ONCM_RAT |
