Description
| Product Name: | Rat IL 7 Recombinant Protein |
| Product Code: | RPPB0544 |
| Size: | 10µg |
| Species: | Rat |
| Target: | IL 7 |
| Synonyms: | Lymphopoietin 1 (LP-1), pre-B cell factor, IL-7. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | Lyophilized from a 0.2�m filtered concentrated solution in PBS, pH 7.4. |
| Solubility: | It is recommended to reconstitute the lyophilized�IL-7 in sterile 18M-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized IL-7 although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL-7 should be stored at 4°C between 2-7 days and for future use below -18°C.Please prevent freeze-thaw cycles. |
| Purity: | Greater than 98.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | DCHIKDKDGK AFGSVLMISI NQLDKMTGTD SDCPNNEPNF FKKHLCDDTK EAAFLNRAAR KLRQFLKMNI SEEFNDHLLR VSDGTQTLVN CTSKEEKTIK EQKKNDPCFL KRLLREIKTC WNKILKGSI |
| Biological Activity: | The ED50 was determined by the dose-dependent stimulation of the proliferation of murine 2E8 cells is less than 0.2ng/ml, corresponding to a specific activity of >5,000,000IU/mg. |
IL-7 is a cytokine important for B and T cell development. This cytokine and the hepatocyte growth factor (HGF) form a heterodimer that functions as a pre-pro-B cell growth-stimulating factor. This cytokine is found to be a cofactor for V(D)J rearrangement of the T cell receptor beta (TCRB) during early T cell development. This cytokine can be produced locally by intestinal epithelial and epithelial goblet cells, and may serve as a regulatory factor for intestinal mucosal lymphocytes. Knockout studies in mice suggested that this cytokine plays an essential role in lymphoid cell survival.
IL 7 Rat Recombinant produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 129 amino acids and having a molecular mass of 15.0kDa.The IL 7 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. |
| NCBI Summary: | hematopoietic cytokine; involved in immune response and brain tumor growth [RGD, Feb 2006] |
| UniProt Code: | P56478 |
| NCBI GenInfo Identifier: | 3024010 |
| NCBI Gene ID: | |
| NCBI Accession: | P56478.1 |
| Molecular Weight: | 15.0 kDa |
| NCBI Full Name: | Interleukin-7 |
| UniProt Protein Name: | Interleukin-7 |
| Protein Family: | Interleukin |
| UniProt Gene Name: | Il7�� |
| UniProt Entry Name: | IL7_RAT |
