Description
| Product Name: | Rat IL 5 Recombinant Protein |
| Product Code: | RPPB0518 |
| Size: | 10µg |
| Species: | Rat |
| Target: | IL 5 |
| Synonyms: | EDF, BCDFII, TRF, T-cell replacing factor, Eosinophil differentiation factor, B cell differentiation factor I, IL-5. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | Lyophilized from a concentrated (1mg/ml) solution in water containing no additives. |
| Solubility: | It is recommended to reconstitute the lyophilized Interleikin-5 Rat in sterile 18M?-cm H2O not less than 100�g/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized Interleukin-5 Rat although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution IL5 Rat should be stored at 4°C between 2-7 days and for future use below -18°C.Please avoid freeze thaw cycles. |
| Purity: | Greater than 95.0% as determined by:(a) Analysis by RP-HPLC.(b) Analysis by SDS-PAGE. |
| Amino Acid Sequence: | The sequence of the first five N-terminal amino acids was determined and was found to be Met-Glu-Ile-Pro-Met |
| Biological Activity: | The ED50 range=0.3-1.0 ng/ml as determined by the dose-dependant stimulation of the proliferation of BCL-1 cells. |
The protein encoded by this gene is a cytokine that acts as a growth and differentiation factor for both B cells and eosinophils. This cytokine is a main regulator of eosinopoiesis, eosinophil maturation and activation. The elevated production of this cytokine is reported to be related to asthma or hypereosinophilic syndromes. The receptor of this cytokine is a heterodimer, whose beta subunit is shared with the receptors for interleukine 3 (IL3) and colony stimulating factor 2 (CSF2/GM-CSF). This gene, together with those for interleukin 4 (IL4), interleukin 13 (IL13), and CSF2, form a cytokine gene cluster on chromosome 5. This cytokine, IL4, and IL13 are found to be regulated coordinately by long-range regulatory elements spread over 120 kilobases on chromosome 5q31.
Interleukin-5 Rat Recombinant produced in E.Coli is a dimeric, non-glycosylated polypeptide chain containing 113 amino acids and having a molecular mass of 13074 Dalton.The IL-5 is purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Factor that induces terminal differentiation of late-developing B-cells to immunoglobulin secreting cells. |
| NCBI Summary: | cytokine with B-cell growth factor activity [RGD, Feb 2006] |
| UniProt Code: | Q08125 |
| NCBI GenInfo Identifier: | 585311 |
| NCBI Gene ID: | 24497 |
| NCBI Accession: | Q08125.1 |
| UniProt Related Accession: | Q08125 |
| Molecular Weight: | 15,207 Da |
| NCBI Full Name: | Interleukin-5 |
| NCBI Synonym Full Names: | interleukin 5 |
| NCBI Official Symbol: | Il5�� |
| NCBI Protein Information: | interleukin-5 |
| UniProt Protein Name: | Interleukin-5 |
| UniProt Synonym Protein Names: | B-cell growth factor II; BCGF-II; Cytotoxic T-lymphocyte inducer; Eosinophil differentiation factor; T-cell replacing factor; TRF |
| Protein Family: | Interleukin |
| UniProt Gene Name: | Il5�� |
