Description
| Product Name: | Rat IL 1RA Recombinant Protein |
| Product Code: | RPPB0474 |
| Size: | 20µg |
| Species: | Rat |
| Target: | IL 1RA |
| Synonyms: | Interleukin-1 receptor antagonist protein, IL-1RN, IL-1ra, IRAP, IL1 inhibitor, Il1rn, Il-1ra, Interleukin-1 Receptor Antagonist, IL-1ra, IL 1RA. |
| Source: | Escherichia Coli |
| Physical Appearance: | Sterile Filtered clear solution. |
| Formulation: | IL 1RA protein solution (1mg/ml) containing Phosphate Buffer Saline (pH7.4), 10% glycerol and 1mM DTT. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 90.0% as determined by analysis by SDS-PAGE. |
| Amino Acid Sequence: | MGSSHHHHHH SSGLVPRGSH MGSHPAGKRP CKMQAFRIWD TNQKTFYLRN NQLIAGYLQG PNTKLEEKID MVPIDFRNVF LGIHGGKLCL SCVKSGDDTK LQLEEVNITD LNKNKEEDKR FTFIRSETGP TTSFESLACP GWFLCTTLEA DHPVSLTNTP KEPCTVTKFY FQEDQ |
Interleukin-1 ra is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
IL 1RA Rat Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 175 amino acids (27-178a.a.) and having a molecular mass of 19.8kDa.IL 1RA is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Inhibits the activity of interleukin-1 by binding to receptor IL1R1 and preventing its association with the coreceptor IL1RAP for signaling. Has no interleukin-1 like activity. |
| NCBI Summary: | binds to IL-1 receptor, blocking the binding of IL-1 alpha and -beta [RGD, Feb 2006] |
| UniProt Code: | P25086 |
| NCBI GenInfo Identifier: | 11559964 |
| NCBI Gene ID: | 60582 |
| NCBI Accession: | NP_071530.1 |
| UniProt Related Accession: | P25086 |
| Molecular Weight: | 20,282 Da |
| NCBI Full Name: | interleukin-1 receptor antagonist protein |
| NCBI Synonym Full Names: | interleukin 1 receptor antagonist |
| NCBI Official Symbol: | Il1rn�� |
| NCBI Official Synonym Symbols: | IL-1ra�� |
| NCBI Protein Information: | interleukin-1 receptor antagonist protein |
| UniProt Protein Name: | Interleukin-1 receptor antagonist protein |
| UniProt Synonym Protein Names: | IL1 inhibitor |
| Protein Family: | Interleukin-1 receptor antagonist protein |
| UniProt Gene Name: | Il1rn�� |
| UniProt Entry Name: | IL1RA_RAT |
