Description
| 抗体名: | RASGRF1 Antibody |
| 抗体コード: | PACO03312 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, IHC |
| 推奨される希釈: | IHC:1:100-1:300 |
| 反応性: | Mouse, Rat |
| 免疫原: | synthesized peptide derived from mouse Ras-GRF1 around the non-phosphorylation site of S916. |
| 憲法: | Liquid |
| ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| 精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
| シノニム: | RASGRF1; CDC25; GNRP; GRF1; Ras-specific guanine nucleotide-releasing factor 1; Ras-GRF1; Guanine nucleotide-releasing protein; GNRP; Ras-specific nucleotide exchange factor CDC25 |
| UniProt Protein Function: | RASGRF1: a guanine nucleotide exchange factor (GEF). Stimulates the dissociation of GDP from RAS protein. Activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit in the mouse brain,. The signaling pathway mediated by this protein may be important for long-term memory. Two alternatively spliced variants have been reported. |
| UniProt Protein Details: | Protein type:GEFs, Ras; GEFs Chromosomal Location of Human Ortholog: 15q24.2 Cellular Component: cytosol; growth cone; plasma membrane Molecular Function:guanyl-nucleotide exchange factor activity; Ras guanyl-nucleotide exchange factor activity Biological Process: MAPKKK cascade; neurite development; positive regulation of GTPase activity; positive regulation of Ras protein signal transduction; regulation of Rac protein signal transduction; regulation of Ras protein signal transduction; regulation of synaptic plasticity; signal transduction |
| NCBI Summary: | The protein encoded by this gene is a guanine nucleotide exchange factor (GEF) similar to the Saccharomyces cerevisiae CDC25 gene product. Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. The studies of the similar gene in mouse suggested that the Ras-GEF activity of this protein in brain can be activated by Ca2+ influx, muscarinic receptors, and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may be important for long-term memory. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Mar 2009] |
| UniProt Code: | Q13972 |
| NCBI GenInfo Identifier: | 613504205 |
| NCBI Gene ID: | 5923 |
| NCBI Accession: | Q13972.2 |
| UniProt Secondary Accession: | Q13972,Q16027, F8VPA5, H0YKF2, J3KQP9, |
| UniProt Related Accession: | Q13972 |
| Molecular Weight: | 143,218 Da |
| NCBI Full Name: | Ras-specific guanine nucleotide-releasing factor 1 |
| NCBI Synonym Full Names: | Ras protein specific guanine nucleotide releasing factor 1 |
| NCBI Official Symbol: | RASGRF1 |
| NCBI Official Synonym Symbols: | GNRP; GRF1; CDC25; GRF55; CDC25L; H-GRF55; PP13187; ras-GRF1 |
| NCBI Protein Information: | ras-specific guanine nucleotide-releasing factor 1 |
| UniProt Protein Name: | Ras-specific guanine nucleotide-releasing factor 1 |
| UniProt Synonym Protein Names: | Guanine nucleotide-releasing protein; GNRP; Ras-specific nucleotide exchange factor CDC25 |
| Protein Family: | Ras-specific guanine nucleotide-releasing factor |
| UniProt Gene Name: | RASGRF1 |
| UniProt Entry Name: | RGRF1_HUMAN |
