Description
| 抗体名: | RAB3IP Antibody, FITC conjugated (PACO48068) |
| 抗体コード: | PACO48068 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA |
| 推奨される希釈: | |
| 反応性: | Human |
| 免疫原: | Recombinant Human Rab-3A-interacting protein (1-132AA) |
| 憲法: | Liquid |
| ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| 精製方法: | >95%, Protein G purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | FITC |
| バックグラウンド: | Guanine nucleotide exchange factor (GEF) which may activate RAB8A and RAB8B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. Mediates the release of GDP from RAB8A and RAB8B but not from RAB3A or RAB5. Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface. Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. |
| シノニム: | Rab-3A-interacting protein (Rab3A-interacting protein) (Rabin-3) (SSX2-interacting protein), RAB3IP, RABIN8 |
| UniProt Protein Function: | RAB3IP: Guanine nucleotide exchange factor for RAB8A. Mediates the release of GDP from RAB8A but not from RAB3A or RAB5. Modulates actin organization and promotes polarized transport of RAB8A-specific vesicles to the cell surface. Together with RAB11A, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Belongs to the SEC2 family. 8 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:GEF; GEF, Rab Chromosomal Location of Human Ortholog: 12q15 Cellular Component: cytosol; nucleus Molecular Function:protein binding; Rab guanyl-nucleotide exchange factor activity Biological Process: protein targeting to membrane |
| UniProt Code: | Q96QF0 |
| NCBI GenInfo Identifier: | 71152025 |
| NCBI Gene ID: | 117177 |
| NCBI Accession: | Q96QF0.1 |
| UniProt Secondary Accession: | Q96QF0,Q6PCE4, Q96A24, Q96QE6, Q96QE7, Q96QE8, Q96QE9 Q96QF1, Q9H673, B7WPJ6, |
| UniProt Related Accession: | Q96QF0 |
| Molecular Weight: | 53kDa |
| NCBI Full Name: | Rab-3A-interacting protein |
| NCBI Synonym Full Names: | RAB3A interacting protein |
| NCBI Official Symbol: | RAB3IP |
| NCBI Official Synonym Symbols: | RABIN3; RABIN8 |
| NCBI Protein Information: | rab-3A-interacting protein |
| UniProt Protein Name: | Rab-3A-interacting protein |
| UniProt Synonym Protein Names: | Rabin-3; SSX2-interacting protein |
| Protein Family: | Rab-3A-interacting protein |
| UniProt Gene Name: | RAB3IP |
