Description
| 抗体名: | PTPRR Antibody (PACO35798) |
| 抗体コード: | PACO35798 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, IHC |
| 推奨される希釈: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
| 反応性: | Human |
| 免疫原: | Recombinant Human Receptor-type tyrosine-protein phosphatase R protein (1-412AA) |
| 憲法: | Liquid |
| ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| 精製方法: | >95%, Protein G purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | Immunohistochemistry of paraffin-embedded human liver tissue using PACO35798 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human kidney tissue using PACO35798 at dilution of 1:100. |
| バックグラウンド: | Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus |
| シノニム: | Receptor-type tyrosine-protein phosphatase R (R-PTP-R) (EC 3.1.3.48) (Ch-1PTPase) (NC-PTPCOM1) (Protein-tyrosine phosphatase PCPTP1), PTPRR, ECPTP PTPRQ |
| UniProt Protein Function: | PTP-SL: Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus. Belongs to the protein-tyrosine phosphatase family. Receptor class 7 subfamily. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; EC 3.1.3.48; Membrane protein, integral; Receptor protein phosphatase, tyrosine Chromosomal Location of Human Ortholog: 12q15 Cellular Component: extracellular space; perinuclear region of cytoplasm; integral to membrane; plasma membrane Molecular Function:protein binding; transmembrane receptor protein tyrosine phosphatase activity; protein tyrosine phosphatase activity; protein kinase binding Biological Process: in utero embryonic development; protein amino acid dephosphorylation |
| NCBI Summary: | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. Silencing of this gene has been associated with colorectal cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares a symbol (PTPRQ) with another gene, protein tyrosine phosphatase, receptor type, Q (GeneID 374462), which is also located on chromosome 12. [provided by RefSeq, May 2011] |
| UniProt Code: | Q15256 |
| NCBI GenInfo Identifier: | 134039192 |
| NCBI Gene ID: | 5801 |
| NCBI Accession: | Q15256.2 |
| UniProt Secondary Accession: | Q15256,O00342, Q92682, Q9UE65, B2R5Z7, B7Z3J1, F5GXR7 |
| UniProt Related Accession: | Q15256 |
| Molecular Weight: | 657 |
| NCBI Full Name: | Receptor-type tyrosine-protein phosphatase R |
| NCBI Synonym Full Names: | protein tyrosine phosphatase, receptor type, R |
| NCBI Official Symbol: | PTPRR |
| NCBI Official Synonym Symbols: | PTPRQ; EC-PTP; PCPTP1; PTP-SL; PTPBR7 |
| NCBI Protein Information: | receptor-type tyrosine-protein phosphatase R; R-PTP-R; NC-PTPCOM1; ch-1PTPase; Ch-1 PTPase; protein-tyrosine phosphatase PCPTP1; protein tyrosine phosphatase Cr1PTPase; protein-tyrosine phosphatase NC-PTPCOM1 |
| UniProt Protein Name: | Receptor-type tyrosine-protein phosphatase R |
| UniProt Synonym Protein Names: | Ch-1PTPase; NC-PTPCOM1; Protein-tyrosine phosphatase PCPTP1 |
| Protein Family: | Receptor-type tyrosine-protein phosphatase |
| UniProt Gene Name: | PTPRR |
| UniProt Entry Name: | PTPRR_HUMAN |
