| UniProt Protein Function: | PTPRF: Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase). Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Membrane protein, integral; EC 3.1.3.48; Receptor protein phosphatase, tyrosine Chromosomal Location of Human Ortholog: 1p34 Cellular Component: integral to plasma membrane Molecular Function:heparin binding; transmembrane receptor protein tyrosine phosphatase activity; protein complex binding; protein tyrosine phosphatase activity Biological Process: cell migration; cell adhesion; transmembrane receptor protein tyrosine phosphatase signaling pathway Disease: Breasts And/or Nipples, Aplasia Or Hypoplasia Of, 2 |
| NCBI Summary: | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains three Ig-like domains, and nine non-Ig like domains similar to that of neural-cell adhesion molecule. This PTP was shown to function in the regulation of epithelial cell-cell contacts at adherents junctions, as well as in the control of beta-catenin signaling. An increased expression level of this protein was found in the insulin-responsive tissue of obese, insulin-resistant individuals, and may contribute to the pathogenesis of insulin resistance. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P10586 |
| NCBI GenInfo Identifier: | 226709091 |
| NCBI Gene ID: | 5792 |
| NCBI Accession: | P10586.2 |
| UniProt Secondary Accession: | P10586,Q5T021, Q5T022, Q5W9G2, Q86WS0, D3DPX6, D3DPX7 |
| UniProt Related Accession: | P10586 |
| Molecular Weight: | 1907 |
| NCBI Full Name: | Receptor-type tyrosine-protein phosphatase F |
| NCBI Synonym Full Names: | protein tyrosine phosphatase, receptor type, F |
| NCBI Official Symbol: | PTPRF |
| NCBI Official Synonym Symbols: | LAR; BNAH2 |
| NCBI Protein Information: | receptor-type tyrosine-protein phosphatase F; LCA-homolog; leukocyte common antigen related; leukocyte antigen-related (LAR) PTP receptor; leukocyte antigen-related tyrosine phosphatase; receptor-linked protein-tyrosine phosphatase LAR; protein tyrosine phosphatase, receptor type, F polypeptide |
| UniProt Protein Name: | Receptor-type tyrosine-protein phosphatase F |
| UniProt Synonym Protein Names: | Leukocyte common antigen related; LAR |
| Protein Family: | Receptor-type tyrosine-protein phosphatase |
| UniProt Gene Name: | PTPRF |
| UniProt Entry Name: | PTPRF_HUMAN |
