The PTMA Polyclonal Antibody (PAC018982) is a valuable tool for researchers studying the PTMA protein, which plays a key role in various cellular processes, including cell proliferation, differentiation, and apoptosis. This antibody, produced in rabbits, demonstrates high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to PTMA protein, researchers can accurately detect and analyze its expression in a variety of cell types, making it an essential component in studies related to cancer biology and cell signaling pathways.
PTMA, also known as Prothymosin alpha, is involved in regulating gene expression and is associated with promoting cell survival and proliferation. Its involvement in cellular processes makes it a promising target for research focusing on cancer development and progression. Understanding the function of PTMA is crucial for developing targeted therapies and diagnostic tools for cancer patients, as well as furthering our knowledge of cell biology and disease mechanisms.
Antibody Name:
PTMA Antibody (PACO18982)
Antibody SKU:
PACO18982
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:5000, IHC:1:25-1:100
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synthetic peptide of human PTMA
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO18982(PTMA Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200).
The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO18982(PTMA Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
Prothymosin α may mediate immune function by conferring resistance to certain opportunistic infections and as oncogenes contributing to cell proliferation and invasion in BC. Silencing of these gene significantly inhibited cell proliferation and invasion, and increased apoptosis in BC cells. Immunohistochemistry showed that PTMA expression levels were significantly higher in BC compared to normal bladder epitheliums.
Synonyms:
prothymosin, alpha
UniProt Protein Function:
PTMA: Prothymosin alpha may mediate immune function by conferring resistance to certain opportunistic infections. Belongs to the pro/parathymosin family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:
Protein type:Cell cycle regulation; Nuclear receptor co-regulator
