Epigenetics & Nuclear Signaling

// system_update_altDatasheetHuman APE1/APE Recombinant Protein The enzyme is known to be a redox factor (Ref-1) stimulating DNA binding activity of AP-1 binding proteins such as Fos and Jun as well as a multifunctional DNA repair enzyme having 5' AP...

// system_update_altDatasheetHuman SMAD4 Recombinant Protein SMAD Family Member 4 (SMAD4) is a cytoplasmic protein that belongs to the Dwarfin/SMAD family. SMAD4 contains one MH1 (MAD homology 1) domain and one MH2 (MAD homology 2) domain. It is the...

// system_update_altDatasheetMouse HER2/ErbB2 Recombinant Protein Epidermal growth factor receptor 2 (HER2), also known as ErbB2, NEU, and CD340, is a type I membrane glycoprotein, and belongs to the epidermal growth factor (EGF) receptor family. HER2...

// system_update_altDatasheetHuman STAT5B Recombinant Protein Signal Transducer and Activator of Transcription 5b (STAT5B) is a member of the STAT family of transcription factors. They are responsible for an array of cellular activities including...

// system_update_altDatasheetHuman STAT6 Recombinant Protein Signal Transducer and Activator of Transcription 6 (STAT6) is a member of the STAT family of transcription factors. At least seven STATs exist: STAT1, 2, 3, 4, 5a, 5b, and 6. They are...

// system_update_altDatasheetHuman ASXL1 Recombinant Protein Putative Polycomb group protein ASXL1 involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as retinoic acid receptors (RARs) and peroxisome...

// system_update_altDatasheetHuman TSC22D1 Recombinant Protein TSC22 domain family, member 1 (TSC22D1) is one of the TGF-beta-stimulated clone-22 (TSC-22). TSC-22 was reported to be a differentiation-inducing factor which negatively regulates the growth...

// system_update_altDatasheetHuman MORF4L2/MRGX Recombinant Protein Mortality Factor 4-Like Protein 2 (MORF4L2) is a member of the mortality factor (MORF) family. MORF4L2 localizes in the nucleus, possessing a protein kinase C phosphorylation site and a...

// system_update_altDatasheetHuman EBP1/PA2G4 Recombinant Protein EBP1, also known as PA2G4, is an RNA-binding protein which belongs to the peptidase M24 family. It can be detected n several cell lines tested, including primary and transformed cell lines...

// system_update_altDatasheetHuman MECP2 Recombinant Protein The MeCP2 helps regulate gene activity (expression) by modifying chromatin, the complex of DNA and protein that packages DNA into chromosomes. The MeCP2 protein is present in cells throughout...

// system_update_altDatasheetHuman TLE3 Recombinant Protein Immunoglobulin superfamily member 11(IGSF11) are expressed on the plasma membrane in the tesis and brain. These IGSF proteins undergo final modifications during capacitation and/or the acrosome...

// system_update_altDatasheetHuman SENP2 Recombinant Protein SENP2 is an enzyme that belongs to the peptidase C48 family. SENP2 is a protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to...

// system_update_altDatasheetHuman Fumarase/FH Recombinant Protein Fumaratase catalyses the reversible hydration/dehydration of fumarate to S-malate and is involved in the tricarboxylic acid or Krebs cycle. Fumarate exists in two forms: a cytosolic form...

// system_update_altDatasheetHuman PPIase/FKBP7 Recombinant Protein PPIase is a member of the immunophilin protein family. It also belongs to the cyclophilin-type PPIase family; PPIL3 subfamily. PPIase contains 1 PPIase cyclophilin-type domain. Members...

// system_update_altDatasheetHuman VDR/NR1I1 Recombinant Protein VDR (vitamin D(1,25- dihydroxyvitamin D3)receptor), also known as NR1I1, belongs to the NR1I family, NR1 subfamily. It is composed of three domains: a modulating N-terminal domain, a...

// system_update_altDatasheetHuman PRPS2 Recombinant Protein Ribose-Phosphate Pyrophosphokinase 2 (PRPS2) is a phosphoribosyl pyrophosphate synthetase that belongs to the ribose-phosphate pyrophosphokinase family. PRPS2 is a homodimer. The active form is...

// system_update_altDatasheetHuman HER2/ErbB2 Recombinant Protein Human epidermal growth factor receptor 2 (HER2) is a type of membrane glycoprotein; and belongs to the epidermal growth factor (EGF) receptor family. HER2 plays a key role in development;...

// system_update_altDatasheetHuman HER2/ErbB2 Recombinant Protein Human epidermal growth factor receptor 2 (HER2) is a type of membrane glycoprotein; and belongs to the epidermal growth factor (EGF) receptor family. HER2 plays a key role in development;...

// system_update_altDatasheetHuman Fumarase/FH Recombinant Protein Fumarate Hydratase (FH) is an enzymatic component of the tricarboxylic acid (TCA) cycle, or Krebs cycle, and catalyzes the formation of L-malate from fumarate. It exists in both a...

// system_update_altDatasheetHuman PCNA Recombinant Protein Proliferating Cell Nuclear Antigen (PCNA) is a protein only expresse in nomal proliferate cells and cancer cells. It is central to both DNA replication and repair. One of the well-established...

// system_update_altDatasheetHuman EIF5A2 Recombinant Protein EIF5A2 is a member of the eIF-5A family. It is a 153 amino acids protein that in humans is encoded by the EIF5A2 gene. EIF5A2 is expressed in ovarian and colorectal cancer cell lines and...

// system_update_altDatasheetMouse SMAD3 Recombinant Protein SMAD3 belongs to the SMAD family. Members of this family mediate signal transduction by the TGF-beta/activin/BMP-2/4 cytokine superfamily from receptor Ser/Thr protein kinases at the cell...

// system_update_altDatasheetHuman BCAS2/DAM1 Recombinant Protein Breast Carcinoma-Amplified Sequence 2 (BCAS2) is a member of the SPF27 family. BCAS2 is a nuclear protein and widely expressed in many rtissues. BCAS2 is identified as being overexpressed...

// system_update_altDatasheetER alpha Recombinant Protein Estrogen Receptor is a major ligand-activated transcription factor belonging to the nuclear hormone receptor superfamily. Estrogen Receptor is composed of several domains important for hormone...

// system_update_altDatasheetHuman ZNF75A Recombinant Protein Zinc Finger Protein 75A (ZNF75A) is a member of krueppel C2H2-type zinc-finger protein family. The human ZNF75 gene is located on Xq26, which has only limited homology (less than 65%) to other...

// system_update_altDatasheetHuman KLF6 Recombinant Protein Krueppel-Like Factor 6 (KLF6) belongs to the krueppel C2H2-type zinc-finger protein family. KLF6 contains three C2H2-type zinc fingers and localizes in the nucleus. The highest levels of Klf6...

// system_update_altDatasheetHuman ZNF70 Recombinant Protein Zinc Finger Protein 70 (ZNF70) is a member of the krueppel C2H2-type zinc-finger protein family. ZFN70 is localized to the cell nucleus and contains eleven C2H2-type zinc fingers. ZFN70 has...

// system_update_altDatasheetHuman Protamine-2/PRM2 Recombinant Protein RRM2 is one of two non-identical ribonucleotide reductase subunits. RRM2 is responsible formation of deoxyribonucleotides from ribonucleotides. The encoded protein (M2) is generated...

// system_update_altDatasheetHuman PARP-3/PARP3 Recombinant Protein Regenerating islet-derived protein 4, also known as REG-like protein, REG4, GISP and RELP, a member of the regenerating gene family belonging to the calcium (C-type) dependent lectin...

// system_update_altDatasheetHuman APE1/APE Recombinant Protein Apurinic-Apyrimidinic Endonuclease 1 (APE1) is required for efficient DNA base excision repair. When the damaged bases in your DNA are removed by the DNA glycosylase; APE1 cuts the AP site...

// system_update_altDatasheetHuman ZBTB17/Miz Recombinant Protein Zinc Finger and BTB Domain-Containing Protein 17 (ZBTB17) belongs to the Kruppel C2H2-type zinc finger protein family. ZBTB17 may function as a housekeeping DNA-binding protein that...

// system_update_altDatasheetHuman UBE2T Recombinant Protein Ube2T is the E2 ubiquitin-conjugating enzyme of the Fanconi anemia DNA repair pathway and it is overexpressed in several cancers; representing an attractive target for the development of...

// system_update_altDatasheetHuman NLK Recombinant Protein Nemo-like kinase contains 1 protein kinase domain and belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family and MAP kinase subfamily. It also contains a TQE activation...

// system_update_altDatasheetMouse VDR/NR1I1 Recombinant Protein VDR (vitamin D(1,25- dihydroxyvitamin D3)receptor), also known as NR1I1, belongs to the NR1I family, NR1 subfamily. It is composed of three domains: a modulating N-terminal domain, a...

// system_update_altDatasheetHuman STUB1 Recombinant Protein E3 Ubiquitin-Protein Ligase CHIP is a cytoplasmic protein. The protein CHIP is highly expressed in the muscles, heart, pancreas, brain and placenta. The TPR domain of CHIP interacts with...

// system_update_altDatasheetRat HER2/ErbB2 Recombinant Protein ERBB2 belongs to the protein kinase superfamily, Tyr protein kinase family and EGF receptor subfamily. It contains a protein kinase domain. ERBB2 is widely expressed in epithelial cells, and...

// system_update_altDatasheetDNA Polymerase Beta/POLB Recombinant Protein Human DNA polymerase β is constitutively expressed in cells. It fills in gaps in DNA that are formed following base excision repair. Repair polymerase that plays a key role in...

// system_update_altDatasheetHuman ELK1 Recombinant Protein E twenty-six (ETS)-like transcription factor 1, also known as Elk1 or Member of ETS oncogene family (ELK1), is a member of the ETS oncogene superfamily which is characterized by a common protein...

// system_update_altDatasheetHuman HOXA1 Recombinant Protein Homeobox protein Hox-A1 is a transcription factor encoded by HOXA1 gene. This gene is one of the four types of homeobox genes each of which contains a homobox DNA sequence that codes for the...

// system_update_altDatasheetHuman UBE2T Recombinant Protein Ubiquitin-Conjugating Enzyme E2 T (UBE2T) is a ligase that belongs to the Ubiquitin-Conjugating Enzyme family. UBE2T accepts the ATP-dependent ubiquitin from the E1 complex and catalyzes its...

// system_update_altDatasheetHuman UBE2W Recombinant Protein Ubiquitin-conjugating enzymes, also known as UBE2W, E2 enzymes and more rarely as ubiquitin-carrier enzymes, perform the second step of protein ubiquitination. The modification of protein with...

// system_update_altDatasheetHuman UBE2A Recombinant Protein Ubiquitin-conjugating enzyme E2 A (also known as HHR6A or UBE2A); encoded by human DNA repair genes HHR6A; belongs to the ubiquitin-conjugating enzymes (E2 enzymes) family and is likely to be...

// system_update_altDatasheetHuman UBE2B/HR6B Recombinant Protein Ubiquitin-Conjugating Enzyme E2 B (UBE2B) is a member of the ubiquitin-conjugating enzyme family. UBE2B accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other...

// system_update_altDatasheetHuman UBE2B/HR6B Recombinant Protein Ubiquitin-Conjugating Enzyme E2 B (UBE2B) belongs to the ubiquitin-conjugating enzyme family. UBE2B is required for the covalent attachment of ubiquitin to other proteins and the...

// system_update_altDatasheetHuman ATF1 Recombinant Protein Cyclic AMP-dependent transcription factor ATF-1(ATF1) which contains 1 bZIP (basic-leucine zipper) domain and 1 KID (kinase-inducible) domain, belongs to the bZIP family. It influences cellular...

// system_update_altDatasheetHuman UBE2A Recombinant Protein Protein ubiquitination is an important cell function for targeting aberrant or short-lived proteins for degradation. The three classes of enzymes that contribute to ubiquitination are...

// system_update_altDatasheetHuman MGMT Recombinant Protein MGMT belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. MGMT involved in the cellular defense against the biological effects of...

// system_update_altDatasheetHuman LSM4 Recombinant Protein U6 snRNA-associated Sm-like protein LSm4 (LSM4) is a member of the snRNP Sm proteins family. Sm-like proteins contain the Sm sequence motif and are thought to form a stable heteromer present in...

// system_update_altDatasheetHuman LSM1 Recombinant Protein U6 snRNA-Associated Sm-Like Protein LSm1 (LSM1) belongs to the snRNP Sm proteins family. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which plays...

// system_update_altDatasheetMouse HER2/ErbB2 Recombinant Protein Epidermal growth factor receptor 2 (HER2), also known as ErbB2, NEU, and CD340, is a type I membrane glycoprotein, and belongs to the epidermal growth factor (EGF) receptor family. HER2...

// system_update_altDatasheetHuman PPIH Recombinant Protein Peptidyl-Prolyl Cis-Trans Isomerase H (PPIH) belongs to the Cyclophilin-type PPIase family that accelerate the folding of proteins. PPIases can catalyze the cis-trans isomerization of Proline...

// system_update_altDatasheetHuman Cyclophilin E/PPIE Recombinant Protein Peptidyl-prolyl cis-trans isomerase E, also known as Cyclophilin E, Cyclophilin-33, Rotamase E, CYP33, PPIE, is an enzyme which belongs to the cyclophilin-type PPIase family of...

// system_update_altDatasheetHuman PPIase/PPIL1 Recombinant Protein Peptidyl-Prolyl Cis-Trans Isomerase-Like 1 (PPIase) belongs to the cyclophilin-type PPIase family. PPIases can accelerate the folding of proteins and catalyze the cis-trans isomerization...

// system_update_altDatasheetHuman TAOK3/JIK/MAP3K18 Recombinant Protein Serine/threonine-protein kinase TAO3, also known as cutaneous T-cell lymphoma-associated antigen HD-CL-09, CTCL-associated antigen HD-CL-09, Dendritic cell-derived protein ...

// system_update_altDatasheetHuman PYM1/WIBG Recombinant Protein Partner of Y14 and Mago (WIBG) is a key regulator of the Exon Junction Complex (EJC). EJC is a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs,...

// system_update_altDatasheetHuman CTCF Recombinant Protein Transcriptional Repressor CTCF (CTCF) belongs to the CTCF Zinc-Finger Protein family. CTCF contains twelve C2H2-type zinc fingers and interacts with CHD8. CTCF is highly expressed in a variety...

// system_update_altDatasheetHuman TFAP2C/AP2-GAMMA Recombinant Protein TFAP2C, also known as AP2-GAMMA, is a member of the activating protein 2 family of transcription factors. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate...

// system_update_altDatasheetHuman HOXB4 Recombinant Protein Homeobox B4 (HOXB4) is encoded by the HOXB4 gene which is a member of the the class I homeobox (HOX) gene family and encodes a nuclear protein with a homeobox DNA-binding domain. These genes...

// system_update_altDatasheetHuman IGF2BP2 Recombinant Protein Insulin-Like Growth Factor 2 mRNA-Binding Protein 2 (IGFBP2) belongs to the RRM IMP/VICKZ family. IGFBP2 is a cytoplasmic protein and contains four KH domains and two RRM (RNA recognition...

// system_update_altDatasheetHuman IA2/PTPRN Recombinant Protein Receptor-type tyrosine-protein phosphatase-like N (PTPRN) belongs to the protein-tyrosine phosphatase family and receptor class 8 subfamily. PTPRN contains 1 tyrosine-protein phosphatase...

// system_update_altDatasheetHuman IA2/PTPRN Recombinant Protein Receptor-type tyrosine-protein phosphatase-like N (PTPRN) belongs to the protein-tyrosine phosphatase family and receptor class 8 subfamily. PTPRN contains 1 tyrosine-protein phosphatase...

// system_update_altDatasheetHuman RRM2B/P53R2 Recombinant Protein Ribonucleoside reductase subunit M2B, also known as RRM2B or p53R2, is an enzyme belonging to the iron-dependent ribonucleotide reductase (RNR) enzyme family which is essential for DNA...

// system_update_altDatasheetHuman STAT6 Recombinant Protein Signal transducer and activator of transcription 6 (STAT6) is a transcription factor that is activated by interleukin-4 (IL-4)-induced tyrosine phosphorylation and mediates most of the...

// system_update_altDatasheetHuman ASF1A Recombinant Protein Human Histone Chaperone ASF1A (ASF1A) belongs to the H3/H4 family of histone chaperone proteins. ASF1A is ubiquitously expressed in many cells and tissues, interacting with histones H3 and H4...

// system_update_altDatasheetHuman ATF2 Recombinant Protein Activating transcription factor 2, also known as ATF2, is a member of the leucine zipper family of DNA-binding proteins that binds to the cAMP response element. Its activity is enhanced after...

// system_update_altDatasheetThymidylate Kinase/DTYMK Recombinant Protein Thymidylate kinase (DTYMK) is a ubiquitous enzyme of about 25 kD which belongs to thymidylate kinase family. DTYMK is important in the dTTP synthesis pathway for DNA synthesis. It...

// system_update_altDatasheetHuman TK1 Recombinant Protein Thymidine kinase 1(TK1) belongs to the thymidine kinase family. It is located in the cytoplasm, and phosphorylated on Ser-13 in mitosis during post-translational modification. Two forms of this...

// system_update_altDatasheetHuman HDGF Recombinant Protein Hepatoma-Derived Growth Factor is a original member of the HDGF family. HDGF is a cytoplasmic protein and contains one PWWP domain. HDGF expression levels are high in the nucleus and cytoplasm...

// system_update_altDatasheetHuman HIF alpha/HIF1A Recombinant Protein HIF-1 alpha, also known as HIF1A, contains 1 basic helix-loop-helix (bHLH) domain, 1 PAC (PAS-associated C-terminal) domain and 2 PAS (PER-ARNT-SIM) domains. It is one of the two...

// system_update_altDatasheetHuman SNU13 Recombinant Protein NHP2-Like Protein 1 (NHP2L1) is a member of the ribosomal protein L7Ae family. NHP2L1 proteinis limited to the nucleus, primarily focused in the dense fibrillar component of the nucleolus...

// system_update_altDatasheetHuman N-Glycosylase/OGG1 Recombinant Protein 8-oxoGuanineDNAGlycosylase/OGG1 removes 8-oxoguanine, a mutagenic base byproduct that occurs when cells are exposed to reactive oxygen. Mitochondrial targeting signal, as well as...