Cell Death

// system_update_altDatasheetRat Galectin/LGALS1 Recombinant Protein Galectin-1 (Gal-1, GAL1), is a member of the galectins, a family of animal lectins ranging from Caenorhabditis elegans to humans, which is defined by their affinity for...

// system_update_altDatasheetHJTB Recombinant Protein Jumping translocation breakpoint, also known as JTB, is a member of the JTB family. Jumping translocation (JT) is an unbalanced translocation that comprises amplified chromosomalsegments jumping to...

// system_update_altDatasheetHuman RACK1/GNB2L1 Recombinant Protein Calmodulin-like protein 3 (CALML3) is similar to that of authentic calmodulin and may actually compete with calmodulin by binding, with different affinity, to cellular substrates...

// system_update_altDatasheetHuman ERN1/IRE1 Recombinant Protein Trypsin-3 is a secreted protease produced by the brain that belongs to the peptidase S1 family. It also goes by Trypsin III, brain trypsinogen, and Serine protease 3 and PRSS3. Trypsin-3 is...

// system_update_altDatasheetHuman Gankyrin/PSDM10 Recombinant Protein Gankyrin is a multicatalytic proteinase oncoprotein consists of 7 ankyrin repeats. Gankyrin is over-expressed in the majority of hepatocellular carcinomas. Gankyrin is involved in the...

// system_update_altDatasheetHuman FIS1 Recombinant Protein Mitochondrial Fission 1 Protein (FIS1) is a member of the FIS1 family. FIS1 is a single-pass membrane protein and contains one TPR repeat. FIS1 is part of the mitochondrial complex that promotes...

// system_update_altDatasheetHuman Galectin-7/LGALS7 Recombinant Protein The Galectin family of proteins; with specificity for Nacetyllactosamine containing glycoproteins; consists of beta-galactoside binding lectins containing homologous carbohydrate...

// system_update_altDatasheetHuman APLP Recombinant Protein Amyloid-like protein 1 (APLP-1) is a member of the highly conserved amyloid precursor protein gene family. APLP1 is a membrane-associated glycoprotein that is cleaved by secretases in a manner...

// system_update_altDatasheetHuman Galectin4/LGALS14 Recombinant Protein Galectin-14 is a member of the Galectin family of carbohydrate binding proteins. The members of Galectin family contain one or two carbohydrate recognition domains, which can bind...

// system_update_altDatasheetHuman Caspase0/CASP10 Recombinant Protein Caspase-10 (CASP10) is a 521 amino acid protein member of the Cysteine-Aspartic Acid Protease (Caspase) family. CASP10 contains two DED (Death Effector) domains and is detectable in...

// system_update_altDatasheetHuman GADD45 gamma/GADD45G Recombinant Protein Growth Arrest and DNA Damage-Inducible Protein GADD45 ? (GADD45G) is a nuclear protein which belongs to the GADD45 family. GADD45G is highly expressed in placenta. GADD45G...

// system_update_altDatasheetBMF/Bcl2 modifying factor Recombinant Protein BMF(Bcl2 modifying factor) belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a...

// system_update_altDatasheetHuman BCL2L1/Bcl-XL Recombinant Protein Bcl-2-Like Protein 1 (BCL2L1) is a member of the Bcl-2 family. BCL2L1 is expressed at high levels in cells that undergo a high rate of turnover, such as developing lymphocytes. BCL2L1...

// system_update_altDatasheetHuman APLP Recombinant Protein APLP1, also known as amyloid-like protein 1, is a member of the highly conserved amyloid precursor protein gene family. APLP1 is a membrane-associated glycoprotein that is cleaved by secretases...

// system_update_altDatasheetHuman TGFBR2 Recombinant Protein TGFBR2 is a single-pass type I membrane protein and contains one protein kinase domain. TGFBR2 exsits as a heterodimeric complex with another receptor protein and binds TGF-beta. Signals...

// system_update_altDatasheetHuman S100A8 Recombinant Protein Protein S100-A8 (also MRP8 and calgranulin A) is a calcium- and zinc-binding protein.It plays a prominent role in the regulation of inflammatory processes and immune response. S100A8 can...

// system_update_altDatasheetHuman CRADD/RAIDD Recombinant Protein The protein CRADD (CRADD) is found in most tissues, with especially high expression in the adult heart, testis, liver, skeletal muscle, fetal liver, and kidney. The CRADD domain consists...

// system_update_altDatasheetHuman BID Recombinant Protein The BID protein, also known as BH3-Interacting Domain Death Agonist (BID), belongs to the Bcl-2 protein family and regulates outer mitochondrial membrane permeability. BID is a pro-apoptotic...

// system_update_altDatasheetMouse CHI3L1/YKL40 Recombinant Protein Chitinase-3-like protein 1 (CHI3L1) is a secreted heparin-binding glycoprotein whose expression is associated with vascular smooth muscle cell migration. CHI3L1 is expressed at high...

// system_update_altDatasheetMouse Galectin/LGALS1 Recombinant Protein Galectin-1 (Gal-1, GAL1), is a member of the galectins, a family of animal lectins ranging from Caenorhabditis elegans to humans, which is defined by their affinity for...

// system_update_altDatasheetHuman PTH2/PTRH2 Recombinant Protein PTH2, also known as PTRH2, is a mitochondrial protein which belongs to the PTH2 family. PTH 2 is released during apoptosis from the mitochondria to the cytoplasm. The natural substrate ...

// system_update_altDatasheetHuman HtrA2/Omi Recombinant Protein High temperature requirement protein A2(HTRA2) is a single-pass membrane protein .It contains 1 PDZ (DHR) domain and belongs to the peptidase S1C family. HtrA2 can be released from the...

// system_update_altDatasheetHuman HtrA2/Omi Recombinant Protein Serine protease HTRA2, also known as high temperature requirement protein A2, Omi stress-regulated endoprotease, Serine protease 25, Serine proteinase OMI and HTRA2, is a single-pass...

// system_update_altDatasheetHuman CHI3L1/YKL40 Recombinant Protein Chitinase-3-Like Protein 1 (CHI3L1) belongs to the glycosyl hydrolase 18 family. CHI3L1 is expressed in activated macrophages, articular chondrocytes, synovial cells as well as in liver...

// system_update_altDatasheetHuman BCL-W/BCL2L2 Recombinant Protein Bcl-2-like protein 2 (BCL2L2) belongs to the Bcl-2 family. BCL2L2 is highly expressed in thebrain, spinal cord, testis, pancreas, heart, spleen, and mammary glands. BCL2L2 is a...

// system_update_altDatasheetHuman Survivin/BIRC5 Recombinant Protein Baculoviral IAP Repeat-Containing Protein 5 (BIRC5) belongs to the IAP family. In the apo state, BIRC5 exists as a homodimer and a monomer in the CPC-bound form. BIRC5 is a protein...

// system_update_altDatasheetBeta-amyloid 39/Beta-APP39 Recombinant Protein Amyloid precursor protein (APP) is a type I transmembrane protein expressed in many tissues and concentrated in the synapses of neurons; and is suggested as a regulator of...

// system_update_altDatasheetHuman ERO1A/ERO1L Recombinant Protein ERO1-Like Protein ? (ERO1L) is an enzyme that belongs to the EROs family. ERO1L is expressed at high level in esophagus and upper digestive tract. ERO1L is an essential oxidoreductase...

// system_update_altDatasheetHuman ATG5 Recombinant Protein ATG5 is an E2 ubiquitin ligase that is involved in autophagy. Its expression occurs at the end of the apoptotic process, following on from caspase activity, and is highly expressed in apoptotic...

// system_update_altDatasheetMouse S100A9 Recombinant Protein S100 protein is a family of low molecular weight protein found in vertebrates characterized by two EF-hand calcium-binding motifs. There are at least 21 different S100 proteins, and the name...

// system_update_altDatasheetHuman PEA15 Recombinant Protein Astrocyticphosphoprotein PEA-15 (PEA15) is a death effector domain (DED)-containing protein. The protein is most abundant in the central nervous system, where it's mostly found in astrocytes...

// system_update_altDatasheetHuman AIFM1 Recombinant Protein Apoptosis-Inducing Factor 1, Mitochondrial (AIFM1) is a flavoprotein essential for nuclear disassembly in apoptotic cells that is found in the mitochondrial intermembrane space in healthy cells...

// system_update_altDatasheetHuman EphA7/EHK3 Recombinant Protein Ephrin Type-A Receptor 7 (EPHA7) is a single-pass type I membrane protein which belongs to the Eph family of transmembrane receptor tyrosine kinases. It contains two fibronectin type-III...

// system_update_altDatasheetHuman PCSK9 Recombinant Protein Recombinant Human Proprotein Convertase Subtilisin/Kexin Type 9/PCSK9 (D374Y) is a gain of function mutant of human PCSK9 protein. Human PCSK9 is a secretory subtilase belonging to the...

// system_update_altDatasheetHuman BID Recombinant Protein The BH3 interacting domain death agonist (BID) is a pro-apoptotic Bcl-2 protein family member that only contains the BH3 domain; it is required for its interaction with the Bcl-2 family proteins...

// system_update_altDatasheetHuman PCSK9 Recombinant Protein Human Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes...

// system_update_altDatasheetHuman PCSK9 Recombinant Protein Human Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes...

// system_update_altDatasheetHuman PCSK9 Recombinant Protein Human Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes...

// system_update_altDatasheetHuman C1D Recombinant Protein C1D nuclear receptor corepressor belongs to the C1D family. It is a DNA binding and apoptosis-inducing protein.C1D nuclear receptor corepressorinteracts with TSNAX and DNA-PKcs. It acts as a...

// system_update_altDatasheetMouse S100A8/CAGA Recombinant Protein Protein S100-A8(Mrp8) contains 2 EF-hand domains and belongs to the S-100 family. Mrp8 binds two calcium ions per molecule with an affinity similar to that of the S-100 proteins. S100...

// system_update_altDatasheetMouse ERK2/MAPK1/MAPK2 Recombinant Protein MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular...

// system_update_altDatasheetMouse PCSK9/NARC1 Recombinant Protein Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes...

// system_update_altDatasheetHuman CASP7/caspase 7 Recombinant Protein Caspase 7, also known as caspase-7 and MCH3, belongs to the cysteine-aspartic acid protease (caspase) family. Caspases play a role in the signal transduction pathways of apoptosis,...

// system_update_altDatasheetHuman DFFA Recombinant Protein DNA Fragmentation Factor Subunit Alpha (DFFA). DFFA exists as a heterodimer (DFF) with DFFB. DFF is activated once DFFA is cleaved by Caspase-3. The cleaved fragments of DFFA detach from DFFB...

// system_update_altDatasheetHuman UBE2Z Recombinant Protein Ubiquitin-Conjugating Enzyme E2 Z (ZUBE2Z) is a member of the E2 ubiquitin-conjugating enzyme family. ZUBE2Z is widely expressed in many tissues, with high expression found in the placenta,...

// system_update_altDatasheetHuman GAPDH Recombinant Protein Glyceraldehyde 3-phosphate dehydrogenase (GAPDH or G3PDH) is an enzyme of about 37kDa that is consisdered as a cellular enzyme involved in glycolysis. It catelyzes the sixth step of glycolysis...

// system_update_altDatasheetHuman PS6K/RPS6KB1 Recombinant Protein PS6K, also known as RPS6KB1, is a serine/threonine-protein kinase. It belongs to the RSK (ribosomal s6 kinase) family. Members of this family function in signal transduction. PS6K is an...

// system_update_altDatasheetHuman UBE2D3 Recombinant Protein UBE2D3 is an enzyme that belongs to the ubiquitin-conjugating enzyme family. The process of ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s,...

// system_update_altDatasheetHuman DYNLL1 Recombinant Protein Human Dynein Cytoplasmic Light Chain 1 (DYNLL1) has been identified as a protein that interacts with NOS1, leading to NOS1 inhibition. NOS1 dimer is destabilized after binding DYNLL1 a...

// system_update_altDatasheetHuman Cytochrome C/CYCS Recombinant Protein Cytochrome C (CYCS) is a small heme protein that belongs to the cytochrome c family. It is found loosely associated with the inner membrane of the mitochondrion. Cytochrome C is a...

// system_update_altDatasheetHuman MKK6 Recombinant Protein Dual specificity mitogen-activated protein kinase kinase 6; also known as MAP kinase kinase 6; MAPKK 6; MAPK / ERK kinase 6; SAPKK3; MAP2K6 and MKK6; is a protein which belongs to the?protein...

// system_update_altDatasheetHuman MKK6 Recombinant Protein Dual specificity mitogen-activated protein kinase kinase 6; also known as MAP kinase kinase 6; MAPKK 6; MAPK / ERK kinase 6; SAPKK3; MAP2K6 and MKK6; is a protein which belongs to the?protein...

// system_update_altDatasheetHuman TGFBR1/ALK-5 Recombinant Protein Transforming growth factor, beta receptor I, also known as Transforming growth factor-beta receptor type I , Serine / threonine-protein kinase receptor R4, Activin receptor-like kinase...

// system_update_altDatasheetHuman CRADD/RAIDD Recombinant Protein Death domain-containing protein CRADD; also known as Caspase and RIP adapter with death domain; RIP-associated protein with a death domain; CRADD and RAIDD; is a protein which is...

// system_update_altDatasheetHuman Cyclophilin D/PPID Recombinant Protein Peptidyl-Prolyl Cis-Trans Isomerase D (PPID) belongs to the cyclophilin-type PPIase family and PPIase D subfamily. PPID is widely expressed and it contains one PPIase...

// system_update_altDatasheetHuman STK4/MST1 Recombinant Protein MST1 protein encoded by this gene contains four kringle domains and a serine protease domain, similar to that found in hepatic growth factor. Despite the presence of the serine protease...

// system_update_altDatasheetBeta-amyloid 40/Beta-APP40 Recombinant Protein Amyloid precursor protein (APP) is a type I transmembrane protein expressed in many tissues and concentrated in the synapses of neurons; and is suggested as a regulator of...

// system_update_altDatasheetBeta-amyloid 42/Beta-APP42 Recombinant Protein Amyloid precursor protein (APP) is a type I transmembrane protein expressed in many tissues and concentrated in the synapses of neurons; and is suggested as a regulator of...

// system_update_altDatasheetBeta-amyloid 38/Beta-APP38 Recombinant Protein Amyloid precursor protein (APP) is a type I transmembrane protein expressed in many tissues and concentrated in the synapses of neurons; and is suggested as a regulator of...

// system_update_altDatasheetRat LCN2/NGAL Recombinant Protein Lipocalin-2 (LCN2), also known as neutrophil gelatinase-associated lipocalin (NGAL), is a 25 kDa protein belonging to the lipocalin superfamily. It was initially found in activated...

// system_update_altDatasheetHuman ERN1/IRE1 Recombinant Protein The encoded protein contains two functional catalytic domains; a serine/threonine-protein kinase domain and an endoribonuclease domain. This protein functions as a sensor of unfolded...

// system_update_altDatasheetMouse NGAL/Lipocalin-2 Recombinant Protein Lipocalin-2, also known as Neutrophil Gelatinase-Associated Lipocalin (NGAL), is a secretory protein of the lipocalin superfamily. Lipocalin-2 contains a signal peptide that enables...

// system_update_altDatasheetHuman DAPK1/DAP Kinase 1 Recombinant Protein Death-associated protein kinase 1, also known as DAP kinase 1, DAPK1 and DAPK, is a cytoplasm protein which belongs to the protein kinase superfamily, CAMK Ser / Thr protein...

// system_update_altDatasheetRat TGFBR2 Recombinant Protein TGFBR2 is member of the Ser/Thr protein kinase family and the TGFB receptor subfamily. It is a transmembrane protein. TGFBR2 is comprised by a C-terminal protein kinase domain and an N-terminal...

// system_update_altDatasheetHuman STK24/MST3 Recombinant Protein MST3 encodes a serine/threonine protein kinase that functions upstream of mitogen-activated protein kinase (MAPK) signaling. The encoded protein is cleaved into two chains by caspases; the...

// system_update_altDatasheetHuman NOL3 Recombinant Protein Nucleolar Protein 3 is encoded by NOL3 gene; multiple transcript variants encoding different isoforms have been found for this gene. So far; Nucleolar protein 3 has show to have two Isoforms...

// system_update_altDatasheetHuman NOL3 Recombinant Protein Nucleolar protein 3 is encoded by NOL3 gene. Multiple transcript variants exist for this gene, each of which encodes a different isoform. So far, two isomeric forms of Nucleolar protein 3 have...

// system_update_altDatasheetHuman Clusterin/ApoJ Recombinant Protein Clusterin is a secreted protein which belongs to the Clusterin family. Clusterin is expressed in adult testis; heart; ovary; adrenal gland; brain and liver. Clusterin has been...

// system_update_altDatasheetMouse NGAL/Lipocalin-2 Recombinant Protein Lipocalin-2, also known as Neutrophil Gelatinase-Associated Lipocalin (NGAL), is a secretory protein of the lipocalin superfamily. Lipocalin-2 contains a signal peptide that enables...

// system_update_altDatasheetHuman Clusterin/ApoJ Recombinant Protein Clusterin is a secreted protein which belongs to the Clusterin family. Clusterin is expressed in adult testis; heart; ovary; adrenal gland; brain and liver. Clusterin has been...

// system_update_altDatasheetHuman BCL2/Bcl-2 Recombinant Protein BCL2 (B-cell leukemia/lymphoma 2, N-Histidine-tagged), also known as Bcl-2, belongs to the Bcl-2 family. Bcl-2 family proteins regulate and contribute to programmed cell death or apoptosis...

// system_update_altDatasheetHuman p63 Recombinant Protein Tumor protein p63 is a protein also known as transformation-related protein 63, TP63, and p63. Tumor protein p63 / p63 is a member of the p53 family of transcription factors whose members P53,...

// system_update_altDatasheetHuman HO/HMOX1 Recombinant Protein Heme oxygenase 1 (HO-1) is an endoplasmic reticulum heme oxygenase enzyme in the heme oxygenase family. HO-1 cleaves the heme ring at the alpha methene bridge to form Biliverdin. Biliverdin...

// system_update_altDatasheetHuman NGAL/Lipocalin-2 Recombinant Protein Neutrophil gelatinase-associated lipocalin(LCN2) is a secreted protein and belongs to the calycin superfamily. This protein is released from injured tubular cells after various...

// system_update_altDatasheetHuman Galectin-7/LGALS7 Recombinant Protein LGALS7; also known as Galectin-7; is a member of the galectins family. The galectins are a family of beta-galactoside-binding proteins. There are at least 14 identified members in...

// system_update_altDatasheetHuman NGAL/Lipocalin-2 Recombinant Protein LCN2 is iron-trafficking protein involved in multiple processes such as apoptosis; innate immunity and renal development. LCN2 binds iron through association with...

// system_update_altDatasheetMouse Osteoprotegerin Recombinant Protein Osteoprotegerin (OPG, Tnfrsf11b) is a secreted protein that regulates bone density. OPG is widely expressed and constitutively released as a homodimer by mesenchymal stem cells,...

// system_update_altDatasheetHuman CEACAM5/CEA Recombinant Protein Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) belong to a group of mammalian immunoglobulin related glycoproteins. They play critical roles in cell–cell recognition...

// system_update_altDatasheetHuman CEACAM5/CEA Recombinant Protein Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) belong to a group of mammalian immunoglobulin related glycoproteins. They play critical roles in cell–cell recognition...

// system_update_altDatasheetHuman HER4/ErbB4 Recombinant Protein ErbB4 is a type I membrane glycoprotein that is a member of the ErbB family of tyrosine kinase receptors. ErbB family members serve as receptors for the epidermal growth factor (EGF)...